There are 13 games on the Sunday schedule in Week 1. Below I will list my favorite Same Game Parlay (SGP) for every single game played on Sunday. Before I get to that, a word (or several) of advice.
First and foremost, bet responsibly. SGPs are longshot bets by nature. As such, I try not to risk a significant percentage of my bankroll on them. I typically risk a quarter of a unit (0.25U) on each SGP I play. Find the ones you like the most from the selections below and go from there.
You should also always be shopping for the best price at multiple sportsbooks if possible. These prices will likely change in the hours leading to kickoff. If any of these drop below the +400 threshold that most books use for promos, you may have to adjust some of the individual lines accordingly.
Now that all of that is out of the way, let's get to the Week 1 NFL Same Game Parlays. Here are our top NFL Same Game Parlay picks for Cardinals vs. Bills. And Boost Your NFL Betting Strategy with Our Same Game Parlay (SGP) Tool!
Best NFL Week 1 Same Game Parlay Bets: Cardinals vs. Bills
The NFL Same Game Parlay Tool is your go-to resource for SGPs in NFL betting. An SGP lets you combine various bets within a single NFL game. Our tool provides insights with correlated bet recommendations, EV ratings, Cover Probability, overall correlation grades, and projections. Additionally, stay connected with our user bet feed to see the latest SGPs placed by fellow bettors.
Cardinals vs. Bills
- Leg 1: Buffalo Bills Moneyline (-295)
- Leg 2: James Cook Over 80.5 Rushing + Receiving Yards (-112)
- Leg 3: James Conner Over 50.5 Rushing Yards (-115)
The Arizona Cardinals should be better on both sides of the ball this season. However, I think it's a bit early for them to compete with a powerhouse like the Buffalo Bills on the road. I believe Buffalo will be able to secure a Week 1 victory.
I also anticipate both starting running backs having solid games in this matchup. Arizona will want to keep Josh Allen off the field. The best way to do that is to feature James Conner against a Buffalo team that has lost several of its key defenders in recent years. Conner should get enough work to get at least 50 rushing yards. He surpassed this number in 10 out of 13 games last year despite Arizona posting a 4-9 record in those outings.
James Cook surpassed this rushing + receiving yards line in six out of nine games after Joe Brady took over offensive coordinator duties midway through last season. With Stefon Diggs out of town, Cook should be able to rack up yards both on the ground and as a receiver out of the backfield. Arizona allowed an average of 151.9 all-purpose yards per game to opposing running backs last season.
Parlay Odds: +440 at BetRivers Sportsbook

