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NFL Week 5 Same Game Parlays & Picks (2025)

Author image by Dan Servodidio | @dan_servodidio | Oct 4, 2025
Author image by Dan Servodidio | @dan_servodidio | Oct 4, 2025
NFL Week 5 Same Game Parlays & Picks (2025)

NFL Week 5 is here, and it's time to lock in some best bets and props before the games kick off. Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same-game parlay (SGP) gives us even more added action. Let's find some plus-money NFL Week 5 same game parlays for every game on the Week 5 Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing, but are always subject to change up until kick-off. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, let's dive into the best NFL Week 5 same-game parlay bets.

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Best NFL Week 5 Same Game Parlays 

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Denver Broncos at Philadelphia Eagles

    Philadelphia just keeps winning games. The 4-0 Eagles have pulled out one-score victories in every game thus far. Maybe this is just what they do, or maybe those tight games are bound to catch up with them. Either way, let's take the Broncos to keep things close enough. 

    Denver easily could be undefeated itself right now. Its two losses both came on game-winning field goals as time expired. Plus, those losses came against a pair of likely playoff teams in the Chargers and Colts. Sean Payton's squad righted the ship with a dominating win over Cincinnati last week. The Broncos can lean on their top-tier defense and exploit some weaknesses in Philly's own defense to keep this tight. 

    Saquon Barkley has been held relatively in check with just 237 rushing yards through four games, averaging only 3.1 yards per carry. Even so, this is the buy-low point. Barkley has still seen 18+ carries in every game, and he's bound to have a 100-yard game. 

    The Eagles will likely have to lean on the run more this week with the Broncos boasting one of the best pass defenses in the NFL. Denver allowed 165 rushing yards to Jonathan Taylor in Week 2, so we know it can be exploited against top backs. Barkley had 60+ rushing yards in 15 out of 16 regular-season games last year. He's also done it twice in four games this season. 

    As for Denver, second-year wideout Troy Franklin has emerged as a top target for Bo Nix. His 18 receptions and 27 targets are both tied with Courtland Sutton for the team lead. In this game, Sutton could be shadowed by stud corner Quinyon Mitchell. That would open up more opportunities for Franklin in softer coverage. Notably, slot-type receivers like Franklin have crushed the Eagles this season: CeeDee Lamb (110 yards), Puka Nacua (112) and Emeka Egbuka (101).

    Parlay Odds: +435 (DraftKings Sportsbook)

    Las Vegas Raiders at Indianapolis Colts

      The Colts should beat the Raiders this week as a touchdown favorite at home. Instead of worrying about the spread or total, though, let's take the over on Indianapolis' team total. The offense is primed to bounce back after being "held" to 20 points on the road against the Rams last week. The Colts are still averaging 30.8 points per game (fourth) and now face a Raiders team that's allowed 41 and 25 points in the past two games. 

      Michael Pittman Jr. should be a key cog for the Indy offense this week. He only had five catches for 41 yards last game, but he still saw a team-high 10 targets. He leads the Colts in receptions and targets this season, while his 234 yards barely trail Tyler Warren. The Raiders have allowed the fourth-most receiving yards to wide receivers this year. That includes Rome Odunze (69 yards), Terry McLaurin (74), Quentin Johnston (71) and Kayshon Boutte (103) all putting up yards in this matchup. 

      On the Vegas side of things, Jakobi Meyers is again someone to target as Geno Smith's favorite receiver. Meyers leads the team in receptions (21), targets (33) and receiving yards (258) this season, with 60+ yards in three out of four weeks. He'll face a Colts defense allowing the fifth-most receiving yards to wideouts this year. Slot receivers like Meyers have particularly done well in this matchup, like Puka Nacua going off for 170 yards versus Indy last week.

      Parlay Odds: +425 (BetMGM)

      New York Giants at New Orleans Saints

        After originally being listed as underdogs, the 0-4 Saints are now favored at home this week against the Giants. Bettors have backed New Orleans to flip these odds, and it's a good chance for the winless NFC South squad to get its first victory of the year. 

        Jaxson Dart looked good and made headlines last week in the home upset of the Chargers. However, it's now a prime letdown spot with the rookie making his first road start in the NFL. It also comes against an underrated Saints defense. Saints defensive coordinator Brandon Staley flamed out as a head coach, but he can still dial up defensive schemes to quiet a rookie quarterback. Plus, the Giants just lost their best offensive player with Malik Nabers out for the season. On the other side, New York's defense continues to be very beatable while allowing the fourth-most total yards per game. 

        Chris Olave, in particular, should play a big role in the Saints' win. The Giants are allowing the second-most receiving yards to opposing wideouts this season. Though Olave has yet to eclipse 60 receiving yards in a game so far, he's been right there with 50+ yards in three out of four weeks. It's also encouraging to see his 43 targets still leading the team by a wide margin. 

        Back to Dart. Even in a losing effort, his rushing production can still be there. The rookie ran for 54 yards on 10 attempts last week, including a rushing score. Dart is clearly looking to use his legs, and the Giants are letting him, whether it's on designed runs or scrambles. Meanwhile, when facing mobile quarterbacks this year, the Saints gave up 45 rushing yards to Josh Allen last week and 38 yards to Kyler Murray in Week 1. 

        Parlay Odds: +475 (BetMGM)

        Dallas Cowboys at New York Jets

          The Cowboys' shaky defense is allowing a league-high 420.5 total yards per game this season. Let's target this matchup once again with a pair of Jets player props. Garrett Wilson and Breece Hall can both go off at home against the Dallas defense. 

          With Wilson, he's been the clear-cut top option in the Jets' passing game. His 27 receptions, 38 targets and 311 yards all lead the team by big margins. Dallas, meanwhile, is allowing the most receiving yards to opposing wide receivers this season. It's a dream matchup for Wilson, who has 80+ yards in three out of four games so far. 

          When it comes to Hall, he should also rack up some yards through the air. The Cowboys have allowed the third-most receiving yards to running backs this year. Hall, meanwhile, already has 13 receptions and 108 yards through four games. He also has 30+ receiving yards in three out of four games. Plus, he's now locked into a bigger role with Braelon Allen sidelined. 

          George Pickens stepped into a featured role in the Dallas offense last week with CeeDee Lamb sidelined. He racked up 134 receiving yards on eight receptions and 11 targets. This should continue, especially with the Cowboys needing to throw more as they struggle defensively. The Jets have allowed 60+ yards to an opposing receiver five times in four games already. 

          Parlay Odds: +405 (DraftKings Sportsbook)

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          Miami Dolphins at Carolina Panthers

            This matchup between the Dolphins and Panthers is essentially a pick'em. You can make a case for either team pulling out the win. Instead, let's just focus on a trio of player props against two subpar defenses. 

            Rico Dowdle steps into the lead back role this week for Carolina with Chuba Hubbard sidelined. We saw last year what Dowdle can do as a starter, when he ran for 1,079 yards on 4.6 yards per carry with Dallas. When he had at least 12 carries in games last season, Dowdle averaged 89.2 rushing yards per contest. 

            Meanwhile, the Dolphins are allowing the third-most rushing yards per game this season. They're also giving up 5.1 yards per carry (fourth-most). It's a prime opportunity for Dowdle to show out in an expanded role. Miami has also allowed at least 98 total yards to an opposing back in every game this year, including Breece Hall's 121 yards and James Cook's 118 yards the past two weeks. Let's just focus on Dowdle's rushing yards, which can eclipse 60+ in this matchup. 

            Darren Waller emerged back onto the scene last week with two touchdowns for Miami on Monday Night Football. All of a sudden, the veteran tight end could be an important part of the Dolphins' passing game with Tyreek Hill now out for the season. He only had 27 yards on three catches, but that might be a floor performance moving forward. This week, he'll face a Panthers defense allowing the second-most receiving yards to tight ends this season. 

            Despite backing Waller, we could still see Tua Tagovailoa's passing yards being capped overall this week. No Hill will mean a less efficient passing game for Miami. Expect the Dolphins to lean on the run, especially since Carolina is more beatable on the ground. The Panthers are actually allowing the ninth-fewest passing yards this year. Instead of worrying about how carries will be split up between De'Von Achane and Ollie Gordon, let's just take the under on Tagovailoa's passing yards. 

            Parlay Odds: +450 (BetMGM)

            Houston Texans at Baltimore Ravens

              Lamar Jackson headlines this week's NFL injury news. The former MVP will likely be sidelined with a hamstring injury suffered last game. That puts Cooper Rush as the Ravens' starting quarterback for this matchup against Houston. As of this writing, Jackson hasn't officially been ruled out, but this week's line movement indicates he very likely won't play. 

              The Texans are now favored on the road after opening as 6-point underdogs. It doesn't take much expert analysis to know that Baltimore's offense gets a huge downgrade with Rush under center instead of Jackson. Plus, the Ravens' defense is allowing a league-worst 33.3 points per game this season. Let's back the line movement and count on Houston to get the win after a 26-0 domination of Tennessee last week. 

              The Texans' offense looked a lot better in the win over Tennessee. C.J. Stroud's improved play was a big reason, but so was Woody Marks. The rookie has quickly emerged as the Texans' go-to running back. He just took on 21 touches for 119 total yards last week (69 rushing and 50 receiving). Marks appears to have the upper hand over Nick Chubb while Joe Mixon remains out. The Ravens are allowing the fourth-most receiving yards and fifth-most rushing yards to opposing backs, so it's a favorable spot. 

              With Jackson out, the Baltimore offense should feature a heavy dose of Derrick Henry in a run-heavy scheme. Houston has been average against the run this year, but it did give up 169 rushing yards on 5.6 yards per carry to Tampa Bay in Week 2. Henry only had 42 yards on eight carries last week, but that should change with Jackson out. Last year, he had 18+ carries in 10 games. 

              Parlay Odds: +355 (DraftKings Sportsbook)

              Tennessee Titans at Arizona Cardinals

                The 0-4 Titans are arguably the worst team in the NFL. They'll likely suffer another loss this week as 7.5-point road underdogs to Arizona. However, let's bank on Tennessee keeping things close enough in the first half. 

                The Titans have usually been more competitive in the first half before falling apart late. They trailed Denver 10-9 at halftime in Week 1 and led the Rams 13-10 at halftime in Week 2. Even in last week's 26-0 loss to Houston, it was just a 6-0 game after two quarters. Arizona, meanwhile, has gotten off to some slow starts while averaging 10.8 points per game in the first half (20th). 

                The Cardinals' offense could also go through some early growing pains as it deals with a banged-up running back room. Trey Benson now joins James Conner on the shelf. That leaves Arizona with Emari Demercado and Michael Carter as the top two options this week. It remains to be seen how the carries and snaps will be divvied up, but let's take a stand on that backfield. 

                There's been some chatter this week that Demercado will remain in his third-down role as the pass-catching back. Carter is also expected to be the leading candidate for early-down carries as the more direct replacement for Trey Benson/James Conner. Let's back Carter for at least 13 rushing attempts. In two games with Conner hurt last year, Carter saw 17 and 13 carries as the lead ball-carrier. If Arizona is leading late, we should also see enough Carter touches in the second half with a favorable game script. 

                For the Titans, Chig Okonkwo should be a safety valve for Cam Ward in this matchup. The tight end only had one catch for four yards last week, but he went for 66 yards on five receptions the game prior. Okonkwo's 13 receptions lead the team so far, which is encouraging. Meanwhile, the Cardinals are allowing the sixth-most receiving yards to tight ends. 

                Parlay Odds: +550 (BetMGM)

                Tampa Bay Buccaneers at Seattle Seahawks

                  The Seahawks are 3.5-point favorites at home against the Buccaneers this week. Seattle should win this game, but it's hard to take a stance on the spread or total. Instead, let's just focus on a trio of Tampa Bay player props for this parlay. 

                  Baker Mayfield has an impressive 8:1 touchdown-to-interception ratio through four games. However, some negative regression on his interceptions could be coming this week. The Seahawks have seven interceptions on the season while allowing just a 76.4 quarterback rating (fourth). Mayfield tossed an interception last week against the Eagles, and he had another one called back due to a penalty. He tossed interceptions in eight road games last year, so he's due after not throwing any in this season's first two road outings. 

                  Bucky Irving is out for Tampa Bay this week, so it moves Rachaad White into the lead back role. We should see White used plenty in the passing game with his pass-catching chops. He had 29 receiving yards on four catches last week while taking more snaps with Irving banged up. Last year, White had 393 receiving yards, even in a complementary role to Irving. We saw White record 549 receiving yards as the lead back in 2023. 

                  As for the Seahawks, they have allowed the most receiving yards to opposing running backs this season. Christian McCaffrey had 73 receiving yards in Week 1 and Jaylen Warren had 86 in Week 2 in this matchup. White should clear his receiving yards line, especially if the Bucs are trailing and Mayfield checks down to his running back enough. 

                  The Seahawks have also allowed the most receptions to tight ends this year. That should mean Cade Otton gets enough volume as an underneath target for Mayfield. He only has 34 receiving yards through four games, but 25 of those came in Week 2. Plus, it's encouraging to see him get four targets and three receptions last week with Mike Evans sidelined. 

                  Parlay Odds: +475 (BetMGM)

                  Detroit Lions at Cincinnati Bengals

                    The Lions come in as double-digit road favorites for this game against Cincinnati. We should see Detroit roll to yet another comfortable victory against one of the worst teams in the league. The spread is a bit too big to trust, though, so let's just focus on some player props. 

                    The Bengals' defense has allowed the third-most passing yards this year. Opposing quarterbacks are also averaging 272.3 passing yards per game in this matchup. It's a prime spot for Jared Goff. The Lions quarterback hasn’t needed to pass much this year, but this defense should allow him to have success through the air. Plus, Goff averaged 260.9 passing yards per game on the road last year and 259.4 in 2023. 

                    Cincinnati is also allowing the second-most rushing yards to running backs this season. We could see both Jahmyr Gibbs and David Montgomery rack up yards in this matchup, especially if the Lions are winning in the second half and leaning on the run. You can certainly look at Gibbs' props, but Montgomery has more value. He was quiet last week, but he ran for 151 and 57 yards in the two games prior. Montgomery only saw nine carries last week, so he's well-rested to take on a bigger load. 

                    For the Bengals' side of things, Chase Brown's rushing yards should be capped in this game. The likely game script certainly points to Cincy throwing more and going away from the run while trailing. Plus, the matchup is a tough one with Detroit ranking fourth in the NFL in defensive rush expected points added (EPA) and seventh in yards allowed per carry (3.8). As for Brown, he's been held to fewer than 50 rushing yards in every game thus far while averaging just 2.3 yards per carry. 

                    Parlay Odds: +480 (DraftKings Sportsbook)

                    Washington Commanders at Los Angeles Chargers 

                        After getting upset on the road by the Giants last week, the Chargers should be in bounce-back mode. Los Angeles now returns home and welcomes another NFC East opponent in Washington. It's a tough spot for the Commanders, going across the country and playing a second straight road game. 

                        The Chargers went 4-2 after a loss last season, as Jim Harbaugh usually got his team back in line after slipping up. Despite last week's loss, Justin Herbert is still playing at an MVP level, and he now faces a Washington defense that just gave up 34 points to Atlanta. Meanwhile, Jayden Daniels is expected to return for the Commanders, but he could be in trouble against the Chargers' loaded defense while playing banged up. 

                        En route to a Chargers’ win, Herbert should throw for a couple of scores. The Commanders have allowed seven passing touchdowns over four games, while Herbert has seven himself. After only throwing one apiece in the past two weeks, a multiple-touchdown effort is bound to come. Washington has allowed three straight quarterbacks to throw for two or more touchdowns. 

                        Herbert should have success through the air overall. Over the past three games, the Commanders have allowed 313 passing yards to Michael Penix, 289 to Geno Smith and 292 to Jordan Love. The defense is also giving up 8.6 yards per completion this season (third-worst). It sets up well for Herbert, who has two 300-yard games already. 

                        Meanwhile, Chargers running back Omarion Hampton should stay hot with his expanded role. The rookie racked up 165 total yards on 17 touches last week, after posting 129 total yards on 25 touches two games ago. He's now the clear lead back with Najee Harris out for the season, and he's taking full advantage. 

                        Parlay Odds: +380 (DraftKings Sportsbook)

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