The 2025 NFL season rolls on with a full Week 6 slate. After the Eagles and Giants kicked things off on Thursday, it's time to get ready for the rest of the week's NFL action. Tracking how much betting lines move during an NFL week can provide useful information to bettors. As sportsbooks collect more information and public or sharp money flows in, lines take more shape.
Each game will have its reasoning for movement (e.g., injuries, betting activity, weather, etc.) and varying degrees of impact on the line. Let's take a look at how the spreads and totals have moved for every remaining NFL game this week.
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NFL Week 6 Line Movement Analysis
The table below summarizes the home team spread and game total movement for this week’s NFL games. Below, we’ll break down some of the more significant line movements.
| Home Spread | Total | ||||||
| Away | Home | Open | Current | Diff | Open | Current | Diff |
| DEN | NYJ | 6.5 | 7.5 | 1 | 43.5 | 43.5 | - |
| NE | NO | 3 | 3.5 | 0.5 | 45.5 | 45.5 | - |
| LAR | BAL | 7.5 | 7.5 | - | 45.5 | 44.5 | -1 |
| CLE | PIT | -6.5 | -5.5 | 1 | 38.5 | 37.5 | -1 |
| ARI | IND | -5.5 | -7.5 | -2 | 47.5 | 46.5 | -1 |
| SEA | JAC | -1.5 | 1.5 | 3 | 44.5 | 47.5 | 3 |
| LAC | MIA | 5.5 | 4.5 | -1 | 45.5 | 44.5 | -1 |
| DAL | CAR | 3.5 | 3 | -0.5 | 47.5 | 49.5 | 2 |
| TEN | LVR | -6 | -4.5 | 1.5 | 42 | 41.5 | -0.5 |
| CIN | GB | -13.5 | -14 | -0.5 | 44.5 | 44.5 | - |
| SF | TB | -2.5 | -3 | -0.5 | 47.5 | 47.5 | - |
| DET | KC | -1.5 | -2.5 | -1 | 49.5 | 52.5 | 3 |
| BUF | ATL | 5.5 | 4.5 | -1 | 49.5 | 49.5 | - |
| CHI | WSH | -4.5 | -4.5 | - | 50.5 | 49.5 | -1 |
(Lines per DraftKings Sportsbook | Line movement via EV Analytics | Opening odds from 9/28 | Current odds as of Thursday evening)
Seattle Seahawks at Jacksonville Jaguars
- Spread Movement: JAC -1.5 to SEA -1.5
- Total Movement: 44.5 to 47.5
We've seen some notable line movement on both the spread and total in this matchup. Some sportsbooks, including DraftKings, have now flipped Seattle to the road favorite after it opened as the underdog in Jacksonville. Plus, the total has risen three full points this week to the current 47.5 over/under.
The Seahawks and Jaguars were on opposite ends of coin-flip games last week. Jacksonville pulled off the improbable home upset over Kansas City on Monday night. Could they be in for a letdown against a non-conference opponent? Seattle is looking to get back on track after suffering a 38-35 defeat to Tampa Bay last week, losing on a field goal as time expired.
As for the total, the Seahawks are averaging 29.2 PPG (5th in NFL) with a top-10 offense in terms of total yards per game. They now face a Jaguars defense that just gave up 476 total yards to the Chiefs in a back-and-forth thriller. The Jags also should've allowed more than 28 points, thanks to an interception on the 1-yard line. Jacksonville comes in averaging 25.4 PPG (10th).
Tennessee Titans at Las Vegas Raiders
- Spread Movement: LVR -6 to LVR -4.5
This is arguably the worst game on the Week 6 slate as a pair of 1-4 teams face off. The Raiders opened as 6-point favorites, but early-week movement has shifted the spread more towards the Titans. We could even see this line move to -3.5, or even -3, by Sunday's kickoff.
Tennessee just pulled off a miraculous comeback last week, scoring 16 points in the fourth quarter to eke out a road upset of Arizona. Can Cam Ward and the Titans ride that momentum into this week's road matchup, or are they in for a letdown?
As for Las Vegas, the Raider have now lost four straight games in what looks to be a lost season. They just suffered a rough 40-6 loss to the Colts and enter this week with the arrow pointing straight down. Yet, they have a get-right opportunity at home here.
Detroit Lions at Kansas City Chiefs
- Total Movement: 49.5 to 52.5
The highest total on the Week 6 slate features the Lions against the Chiefs. The over/under has increased three full points over the week as we have two offenses in a rhythm right now. It sets up to be a back-and-forth shootout on Sunday Night Football.
Is the Kansas City offense back? The Chiefs have scored 37 and 28 points in the past two games. The return of Xavier Worthy has made the attack much more dangerous with the added speed and playmaking. Last week, KC put up 476 total yards of offense and could've scored more if not for an interception on the goal line.
As for Detroit, it's averaging a league-leading 34.8 PPG with at least 34 points in four straight games. The Lions are rolling offensively and showing no signs of slowing down. They can keep it going against a Chiefs defense that's on short rest and just gave up 24 second-half points to the Jaguars.
Arizona Cardinals at Indianapolis Colts
- Spread Movement: IND -5.5 to IND -7.5
According to the latest injury report and the line movement, Kyler Murray may be sidelined for Arizona this week. The Cardinals' dynamic quarterback injured his foot in last week's loss to Tennessee, and he's since been held out of practice. In Murray's absence, the veteran Jacoby Brissett is expected to start.
The betting public and the oddsmakers have reacted accordingly to the Murray injury news. The Colts are now 7.5-point home favorites as of Friday morning. The spread moving past the key number of 7 is notable, as a comfortable Indianapolis win is expected.
The Colts are averaging 32.6 PPG this season (2nd in NFL), and they just demolished the Raiders, 40-6. Meanwhile, Arizona blew a big lead against the Titans last week and lost in embarrassing fashion. Brissett is a respected veteran, but he didn't look good last year in limited action with the Patriots. It could be a long day for the Cardinals' offense trying to keep pace with the Indy attack.
