76ers vs. Knicks NBA Picks & Props (Tuesday)

The Philadelphia 76ers and New York Knicks open their 2026-27 NBA schedules with an Atlantic Division showdown on Tuesday, October 20. Tipoff is scheduled for 7:00 p.m. ET on NBC, with the Knicks listed as 4.5-point home favorites and the total at 232.5. Philadelphia looks to spoil New York's home opener, while the Knicks aim to begin the season with a win over a division rival. Below, we examine our 76ers vs. Knicks picks and predictions, including the betting odds and best bets for NBA opening night.

Best NBA Picks & Predictions: 76ers vs. Knicks

Here are our top picks and predictions for 76ers vs. Knicks.

Philadelphia 76ers at New York Knicks Picks

The defending NBA champions will raise their championship banner against the new-look 76ers, and I like the Knicks to win this game convincingly. While the 76ers have added plenty of new talent, including LeBron James and Jaylen Brown, I'm expecting some early-season struggles as the stars learn to play together.

All five of the 76ers' opening day starters averaged at least 16 points per game last season. Four averaged at least 20.9 points per game, and three averaged at least 26.9 points per game. But there is only one ball, and I want to see how this team plays when one player is hot, or when one is off his game. There's undeniable star power. On paper, the 76ers may seem like the better team, but after what the Knicks did last season, it's hard to argue they’re a more cohesive unit.

Jalen Brunson averaged 26 points per game last season, and in the postseason, he averaged 29 per game in a four-game sweep of the 76ers. Though Mitchell Robinson is now with the Celtics, the Knicks return their entire NBA Finals starting five, with Josh Hart, Mikal Bridges, OG Anunoby and Karl-Anthony Towns all set to play. In what is sure to be an electric environment, I’m giving the advantage to the Knicks over a stacked 76ers team.

Pick: Knicks -4.5 (-108)

Philadelphia 76ers at New York Knicks Player Props

LeBron James didn’t leave his life on the West Coast to have fun in the City of Brotherly Love. He left to compete for a championship as a “Swiss Army knife” on a Philadelphia roster filled with elite talent. At this point in his career, James has the skills to serve as both a facilitator and a scorer. The four-time MVP has proven that by averaging over 20 points, six rebounds and seven assists in each of his previous three campaigns.

James flashed glimpses of what is to come during the 76ers’ final preseason game. An alley-oop slam dunk and a few crafty passes down the court highlighted an exciting performance (eight points, eight rebounds and seven assists in 25 minutes). Keep in mind that James has tallied at least 31 combined points + rebounds + assists in each of his past 10 battles against the Knicks, including four triple-doubles in that stretch. Trust him to ball out inside Madison Square Garden.

LeBron James Over 30.5 Points + Rebounds + Assists (-110)

NBA Player Prop Bet Cheat Sheet: 76ers vs. Knicks

Welcome to your ultimate resource for NBA player props & bets, where we’ve done the heavy lifting to bring you the most informed and profitable picks. By compiling data from multiple projection sources, we’ve created a robust consensus projection that serves as the foundation for our analysis. Next, we meticulously compared these projections with the prop bet odds from leading sportsbooks, ensuring you get the most accurate and advantageous NBA prop bet picks. With our comprehensive approach, you can confidently place your bets, knowing that you have the edge in the ever-competitive world of NBA player prop betting. Let’s check out the top NBA player props, bets, and picks for 76ers vs. Knicks.

What are Player Props?
Player props refer to wagers that bettors can make based on player performance in a specific game. The majority of player props are built around the most common statistical benchmarks for a specific sport, such as yards and touchdowns in football. Most player props are straight over/under plays that open at or near -110 and are adjusted based on where the money lands. Examples of basketball player prop bets include over/under bets on points, assists, rebounds, three-pointers made, blocks, or steals.

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