College Football Picks: Ohio State vs. Indiana (Saturday)

No. 4 Ohio State travels to Bloomington to face No. 5 Indiana on Saturday, October 17, in one of Week 7's marquee college football matchups. The Buckeyes enter as 3.5-point road favorites, with the total set at 50.5 points for the noon ET kickoff at Memorial Stadium. Our Ohio State vs. Indiana best picks and predictions examine the spread, over/under and key matchup factors as these top-five Big Ten teams square off.

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College Football Week 7 Picks & Bets: Ohio State vs. Indiana

Week 7 is shaping up to be among the biggest slates in the 2026 college football season on Saturday. Massive matchups can be found across the board, with 6 head-to-head games between current AP Top 25-ranked opponents. Here are our top college football picks for Ohio State vs. Indiana.

Ohio State (4) vs. Indiana (5)

Undefeated Indiana hosts Ohio State for a top-5 Big Ten tilt in Bloomington to open up Saturday’s Week 7 slate. This Big Noon Kickoff matchup will likely be another low-scoring affair, as both programs have a top-10 scoring defense.

Since lines were released, the point total has bounced between 49.5 and 51.5. We’re getting it right in the middle at 50.5 right now.

It took Indiana until the 4th quarter to find the end zone against Nebraska last week. Ohio State’s schedule, aside from Iowa, has been soft, so expect a lot of grit and resistance in a game that should see both defenses step up to challenge the opposing offense.

Each of the Buckeyes’ previous 7 road games has gone under the point total line. Let’s back this trend and bet Under 50.5 points between Ohio State and Indiana.

Pick: Under 50.5 (-110)