If Wednesday’s MLB games play out anything like Monday’s at the start of the week, we should be in for some real slugfests. Each of the first nine games in the 10-game slate went over the projected total, and the winning team scored eight or more runs in eight of the games. Great news for MLB home run props.
From a home run perspective, nine players started the week with multiple home runs, tied for the second-most players with multi-homer games on the same day in MLB history. That included a head-to-head battle of future Hall of Famers with Mike Trout and Aaron Judge each homering twice in the series opener in the Bronx.
With warm weather gracing most of the country, I’m excited to dive into more of my top MLB home run picks for Wednesday’s loaded 15-game slate.
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Wednesday’s Best Home Run Props
(Odds courtesy of DraftKings Sportsbook)
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Brandon Lowe (+399)
Among starting pitchers who had thrown a minimum of 10 innings entering Tuesday, Nationals righty Jake Irvin was one of 19 who had a HR/9 rate of 1.93 or worse.
KEEP. THEM. HOISTED.
BRANDON LOWE MAKES IT 15-1 WITH A NO-DOUBTER. HE HAS 5 RBI TONIGHT. MY CAPS LOCK BUTTON IS PERMANENTLY STUCK.
104.5 MPH exit velocity, 410 feet, HR in 30/30 ballparks pic.twitter.com/QW3kSoAu9P
— Platinum Key (@PlatinumKey13) April 14, 2026
Irvin has been tagged for three home runs in 14 innings thus far, and Pirates slugger Brandon Lowe has taken him deep once in five career at-bats. After Lowe’s two-home run performance in the series opener, he led the team with six long balls and a .648 slugging rate, while ranking second on the team in wRC+ (186).
Ronald Acuna Jr. (+313)
Marlins righty Chris Paddack has allowed a 2.70 HR/9 rate so far this season. And among those pitchers with a minimum of 10 innings, he has the 13th-worst batting average on balls in play (BABIP) allowed (.387). While the metrics suggest he is due for positive regression since his 3.28 xFIP is much better than his actual FIP (5.69), he is facing the wrong lineup entering a start where he is struggling.
Prior to Atlanta scoring four runs in Monday’s series-opening loss, the Braves had won four of the previous five games while outscoring opponents 39-16 in that span. Considering they were shut out in that only loss, that 9.75 runs per game average during their wins is intimidating.
Ronald Acuna Jr. is 0-for-5 in his career against Paddack, but he was coming on strong with five extra-base hits in the previous five games before Tuesday. He should take advantage of Paddack’s 43.8% hard-hit rate allowed, even though the righty has pitched to a 1.69 ERA in three career starts at Truist Park.
Shea Langeliers (+390)
I will look to take advantage of home run props often when the Athletics play home games in the bandbox that is Sutter Health Park in Sacramento.
Shea Langeliers has two hits in three at-bats in a small sample size against Rangers righty Kumar Rocker, who is arguably the weakest arm in the Rangers’ rotation. Langeliers started the season with four home runs in five games, which was tied for the franchise record for homers through the first five games in a season. Then the next day, he hit a solo home run off Chris Sale, which was the team's only hit against the southpaw.
At that time, Langeliers’ .680 slugging rate was the highest in the Majors since the 2025 All-Star break (minimum 175 plate appearances). In that span, he also ranked fourth in batting average, tied for third in home runs, third in wRC+ and second in fWAR.
Mike Spector is a featured writer at BettingPros. For more from Mike, check out his archive and follow him @MikeSpector01.