Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this Sunday’s NFL slate.
Go premium to view top prop bets based on Cover Probability, Expected Value & Star Rating >>
NFL Odds, Picks & Predictions
Colts vs. Falcons
The Indianapolis Colts are firmly in the playoff conversation with an 8-6 record. The Colts even have a head coach who will be in the running for the Coach of the Year this season. Meanwhile, Indianapolis will face an Atlanta Falcons team that has a coach on the hot seat in Arthur Smith. The Falcons most recently lost to a one-win Panthers team last week. Smith benched Bijan Robinson, and the offense failed to find any consistency in the loss. Therefore, Atlanta will start Taylor Heinicke over Desmond Ridder, looking to find more offense. The Falcons have played a lot of musical chairs with their two quarterbacks, benching both at times during the season. I wouldn't trust Atlanta, even at home, with how things have gone this season. Give me the Colts.
Pick: Colts +2.5
-Jason Radowitz
Seahawks vs. Titans
Geno Smith returned to practice on Wednesday and is in line to start for the Seahawks. It's not official and likely won't be until game time, but Smith hopes to play for Seattle. The Seahawks are 7-7 on the season and need a solid final three weeks to make the playoffs. They'll play a road game against the Titans, who could be without Will Levis due to an ankle sprain. Tennessee would have to play Ryan Tannehill, who isn't a bad second option in the grand scheme of things. However, Derrick Henry might not even earn 1,000 yards rushing this season. DeAndre Hopkins has caught for more yards than Henry has rushed this season. Nobody expected that. While Seattle's run defense has been poor, the pass rush and secondary should do its part to escape with a win over Tennessee.
Pick: Seahawks -3
-Jason Radowitz
Lions vs. Vikings
The Vikings, fighting for their playoff lives, will look to Nick Mullens again to get them over the hump as home underdogs to the Lions. Mullens has looked fairly impressive in his time taking over the Vikings offense. Against Las Vegas he was inserted into the lineup and led the team on their game-winning drive. He followed it up with an impressive 303-yard and 2-TD game against the Bengals, but his 2 INTs proved costly. He’ll go up against a Detroit pass defense that ranks middle of the pack in DVOA and has struggled mightily on the road, allowing 33 points per game in their last four road contests. Detroit is coming off of a big get-right spot after some mid-season struggles. A key factor was the offensive line being healthy and paving lanes for their two-headed running game that is top four in DVOA. Minnesota has been strong defensively, getting pressure on the quarterback. Detroit’s healthy offensive line could play a key role in keeping QB Jared Goff on his feet. Detroit will also be playing for a division title for the first time in 30 years so they should come out firing. Both offenses should find success in this game, making the over a strong play.
Pick: Over 47.5
-Ryan Rodeman
Commanders vs. Jets
With Zach Wilson concussed, Trevor Siemian will likely get the start for the Jets. New York's offense has scored just over 14 points per game. Siemian isn't a better option than Wilson. However, the Jets are facing a defense that has allowed over 30 points per game this year. Washington has allowed nearly 265 yards in the air and another 120 yards on the ground per game. This is the best chance for the Jets' offense to score some points. If New York is able to put points on the board, the defense that has allowed only 170.43 yards in the air and 127.93 yards on the ground should do enough to get New York the win. It's also unclear who Washington will start. But if it's Sam Howell, the Jets will be licking their chops, knowing they'll be able to force turnovers.
Pick: Jets -3
-Jason Radowitz
Packers vs. Panthers
The Carolina Panthers earned their second win of the season last week. But that'll likely be their last win of the season. They'll take on a Packers team that is still fighting for a playoff spot in the NFC. It'll be difficult with a 6-8 record. However, Green Bay isn't mathematically eliminated. The Packers need to perform better defensively. At this time, defensive coordinator Joe Barry has three more opportunities to prove that he belongs as the coordinator in the future. The Packers will likely perform better defensively with the entire unit really digging in, especially against a pitiful Panthers offense. Meanwhile, the Packers have consistently scored 20 points, while the Panthers haven't seen 20 points in the last five games.
Pick: Packers -5
-Jason Radowitz
Browns vs. Texans
CJ Stroud has officially been ruled out of this game so the Texans will be looking to Case Keenum again after he led them to a come from behind overtime victory last week against Tennessee. He’ll face a Cleveland defense that has been relied upon heavily with all of the uncertainty at quarterback all season due to injury. The Browns have had the top ranked defense by most advanced metrics and it’s been led by an elite pass rush. However, they really haven’t played as well on the road. They’ve allowed 30.7 points per game on the road with a 2-4 record. Offensively, the move to Joe Flacco at quarterback hasn’t sparked much. He threw 3 terrible interceptions last week and although Houston’s pass defense hasn’t been great, the Browns don’t have the firepower to take advantage of it. With both teams fighting for a spot in the playoffs this is a key game. I’ll be backing the home underdog.
Pick: Texans +3
-Ryan Rodeman
Jaguars vs. Buccaneers
The Jaguars come into this game on a three-game losing streak, and they were just thrashed by the Ravens 23-7. Injuries have played a large part; they lost Christian Kirk for the year, and Trevor Lawrence has been dealing with an ankle issue and is in concussion protocol. The Buccaneers are red hot at the moment, winning three straight and looking to be heading towards another NFC South championship. Baker Mayfield is having a great comeback story as his 28 touchdowns are eighth, and he's coming off throwing for 381 yards, which is his best since 2018, and four touchdowns. This is another great matchup for Baker and this passing offense, who are 30th in passing yards allowed.
Pick: Bucaneers -1.5
-John Supowitz
Cardinals vs. Bears
This is one of the harder games to handicap in Week 16. The Bears have played better as of late, but are they really worthy of laying four points against anyone at home given their inability to close out games? On the flip side, Arizona isn't a team I'm actively looking to bet on, as they're an even 7-7 ATS as an underdog this year. The situation says to bet Arizona, but I can't get behind a Cardinals team that ranks dead-last in defensive EPA, dead last in pressure rate, and 31st in net yards per pass attempt allowed. As erratic as Justin Fields has been, this feels like a get-right spot for him and Chicago's offense. I'd wait to see if this line drops to Chicago -3, but would lean the Bears at the current number.
Pick: Lean Bears -4
-Matt Barbato
Cowboys vs. Dolphins
This is a phenomenal matchup between two of the best teams in the league this year. Miami’s star WR Tyreek Hill missed last week after injuring his leg the week before. He still may play but is listed as questionable for Sunday. Frankly, it won’t matter. Dallas has been getting gashed on the ground by opponents. Their run defense ranks 16th in DVOA and are averaging 191.8 rush yards against in their four losses, all of which took place on the road. The Dolphins happen to have one of the best offensive rush attacks in the league, as well as an explosive pass game. It’s hard to imagine that Dallas has figured out their run defense woes in just a week’s time. If Miami is dictate the pace of the game, Dallas might have a tough time keeping up. The Dolphin defense is starting to come into form over the last month and a half. A rough ending to the Tennessee game aside, the Dolphins haven’t allowed more than 21 points since October 22nd to the Eagles. Much like we’ve seen when Dallas has played elite run offenses this season, Miami should have no trouble scoring in this game and they’re great value at this current number.
Pick: Dolphins -1.5 (-110)
-Ryan Rodeman
Patriots vs. Broncos
Last week was tough for the Broncos, who came in playing so well, but they still have a realistic shot at getting into the playoffs in a wide-open AFC. The defense had been playing so well until last week, allowing under 20 points in eight straight, and those were against Houston, Buffalo, and Kansas City. Don't be surprised if you see that defensive play return against the Patriots. This offense continues to struggle by scoring just 13 points per game, and while they have done better scoring in the double digits recently, the unsettling play of Mac Jones and Bailey Zappe has made the Pats try and change the lineup frequently this year. We've seen some ugly offense performances from both teams. They each have games that finished in the 20s, so the under-35 is a good play.
Pick: Under 35
-John Supowitz
Subscribe: Apple Podcasts | Spotify | Google Podcasts | RadioPublic | Breaker | Castbox | Pocket Casts
Whether you're new to sports betting or a betting pro, our Sports Betting Strategy and Advice page is for you. You can get started with our 101 section - including 10 Sports Betting Tips for Beginners - or head to more advanced strategy - like Key Numbers When Betting Against the Spread - to learn more.