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NFL Week 2 Odds, Picks & Predictions: Colts vs. Jaguars (2022)

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Here is our preview and best bet for the 2022 NFL Week 2 game between the Colts vs. Jaguars.

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NFL Week 2 Odds, Picks & Predictions: Colts vs. Jaguars

The Colts travel to Jacksonville for a Week 2 AFC South matchup. Indianapolis continued their trend of slow starts with a tie to Houston in which they were only able to muster a field goal through the first three quarters. Matt Ryan fumbled four times, losing only one, and threw an interception in his Colts debut, reminding fans of Carson Wentz. On the other side of the ball, Jacksonville will pose a bigger threat offensively for Indianapolis, as they were able to move the ball effectively on the ground in their Week 1 matchup with the Commanders to the tune of 6.8 yards per carry. The Colts have the firepower to exploit the Jaguars’ defense, but if they start slow again, they may find it too difficult to turn it on late again in the Florida humidity.

Picks: Jaguars +3.5 | Lean u45.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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