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NFL Week 2 Odds, Picks & Predictions: Panthers vs. Giants (2022)

by September 16, 2022
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Here is our preview and best bet for the 2022 NFL Week 2 game between the Panthers vs. Giants.

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NFL Week 2 Odds, Picks & Predictions: Panthers vs. Giants

The Panthers were one of the worst teams against the run last week, and the Giants had the most rushing yards in Week 1. Saquon Barkley should pick up right where he left off against the Titans when he scored the game-winning two-point conversion. He also ran the ball 18 times for 164 yards, an average of 9.1 yards per carry. The Panthers gave up 5.6 yards per attempt against Nick Chubb and the Browns last week.

Baker Mayfield was sacked four times by the Browns last week, and Daniel Jones was sacked five times. The Giants have a better chance at pressuring the quarterback, especially if Kayvon Thibodeaux suits up, but the secondary will need help after allowing 13.3 yards per completion last week. Mayfield threw for 12.9 yards per completion; he may connect on a few deep balls.

Picks: Giants -1.5 | Lean o43.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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