NFL Week 2 Odds, Picks & Predictions: Seahawks vs. 49ers (2022)

Here is our preview and best bet for the 2022 NFL Week 2 game between the Seahawks vs. 49ers.

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NFL Week 2 Odds, Picks & Predictions: Seahawks vs. 49ers

Geno Smith and the Seahawks look to carry momentum from Week 1 as they travel to San Francisco. The Seahawks benefitted from two costly Broncos goal-line fumbles on their way to an outright win, while the 49ers found themselves in a sloppy game at Soldier Field where they found defeat at the hands of Chicago.

With the injury to Elijah Mitchell, the 49ers start with a disadvantage in their run attack and will look to Jeff Wilson and others to pull their weight against a Seattle defense that allowed 5.15 yards per carry in Week 1. On the other side, the Seahawks will have to find their running game if they look to compete. Rushing for only 76 total rushing yards in Week 1, they now face a dynamic front four led by Nick Bosa. Let’s also not forget about the hopeful return of veteran TE George Kittle.

Picks: San Fransisco -9.5 | lean o41.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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