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NFL Week 2 Odds, Picks & Predictions: Titans vs. Bills (2022)

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Here is our preview and best bet for the 2022 NFL Week 2 game between the Titans vs. Bills.

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NFL Week 2 Odds, Picks & Predictions: Titans vs. Bills

Josh Allen and the Bills looked unstoppable in their blowout win over the Rams in Week 1. They will look to continue the dominance as they host the Titans, who enjoyed a defensive first-half shutout to the Giants only to be outscored 21-8 in the second half to squander the win away.

Allen is undoubtedly a unique athletic specimen, but the Titans got a taste of a mobile QB in Daniel Jones last week and kept him to just 25 yards on the ground. If the Titans want to keep the game close, limiting Allen’s rushing yards will be imperative.

For the Bills, spreading the ball around was a point of emphasis last week. With three backs with over five rushes and six receivers with multiple receptions, the talent on the field is imperative. If they can continue to count on their second and third options, the Bills will be very tough to beat.

Picks: Lean Titans +10 | u48.5

What is Betting Against the Spread?

Betting “against the spread” refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


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