NFL Week 6 Odds, Picks & Predictions (Sunday)

Gear up for another weekend of NFL action! Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this Sunday’s NFL slate.

Go premium to view top prop bets based on Cover Probability, Expected Value & Star Rating >>

NFL Odds, Picks & Predictions

Ravens vs. Titans

The Ravens and Titans travel to London for another international game. The Ravens offense just hasn’t looked right this year, but the defense has remained elite. Ranking 2nd in DVOA defense, the Ravens are two odd late blown games away from a 5-0 game. The Titans should struggle in this matchup and it will come down to whether or not their defense can slow down Lamar Jackson. The transition to new offensive coordinator Todd Monken hasn’t been extremely smooth, but a big reason is because of drops by Ravens receivers. I don’t expect that to continue, especially against a Titans defense that ranks 28th in DVOA pass defense. This is a perfect “get right” spot for the Ravens against a Titans team that showed their true colors falling to Gardner Minshew and the Colts last week. I’ll back Baltimore

Pick: Ravens -4

-Ryan Rodeman

Commanders vs. Falcons

The Commanders had a great start to the season, but they've now last three straight, which includes giving the Bears their first victory in almost a year. The offense is middle of the pack, and although Sam Howell's 6-6 TD-INT looks bad, four of those stem from one game. It's been the defense that's underperformed, allowing the second-most points, and they have a ton of injuries on that side of the ball, including one of the top defensive backs in Darrick Forrest, who just went on IR. The Falcons have taken positive steps this year with, and they are a playoff contender. Last week, Desmond Ridder had his first-career 30 passing yard game, and Bijan Robinson has some mixed performances and has yet to run for a touchdown. I'm not too confident in the Falcons defense either, and Atlanta doesn't have a signature win that gives me confidence they can win, but I think this total is too low.

Pick: Over 42

-John Supowitz

Vikings vs. Bears

Has the Chicago Bears offense turned a corner? While putting up big numbers against the Denver Broncos and Washington Commanders defenses doesn't guarantee a turnaround, Justin Fields' play has certainly been encouraging. And there's no reason to believe Fields can't continue his hot streak against a miserable Vikings defense that ranks 28th in EPA pass defense and is entirely dependent on blitzing to generate pressure. Under new defensive coordinator Brian Flores, Minnesota has blitzed 56.2% of the time, by far the highest percentage in the league. However, that aggressive scheme has resulted in a pressure rate of just 21.4% and only 13 sacks. Over the last two weeks, Fields has been blitzed on 22 dropbacks and has been sacked seven times. However, Fields has only thrown six poor passes in those two games and averaged 5.5 air yards per attempt. While I hardly trust this Bears defense, I'm concerned about what the Vikings offense will look like without Justin Jefferson, as Jordan Addison is inexperienced and K.J. Osborn is hardly a dynamic pass catcher. Take the home divisional dog here.

Pick: Bears +3

-Matt Barbato

Seahawks vs. Bengals

It took five games, but Joe Burrow finally looks right. He exploded for 317 yards and 3 TDs on the road against the Cardinals in Week 5. Arizona isn’t a top tier pass defense by any measure, but the Seahawks aren’t either. Seattle sits at 25th in pass defense DVOA. Matthew Stafford, Jared Goff and even Andy Dalton all had solid days against the Seahawks. On the other side, Cincinnati has been able to get to the quarterback at a solid rate. They’re 9th in adjusted sack rate in the league. The Rams were able to disrupt Geno Smith often in their dismantling of the Seahawks in Week 1 and if Cincinnati can get similar pressure, Smith could have another long day. I think the market is hesitant to believe what we saw from the Bengals last week was real, but we have two full seasons of what Burrow can be when he’s healthy and it appears he finally is.

Pick: Bengals -2.5

-Ryan Rodeman

49ers vs. Browns

Heading into the week, this felt like an incredible spot to take the underdog Browns against the undefeated 49ers. Well, now Deshaun Watson is sidelined for the second straight week. That means PJ Walker will be under center for the Browns, which could be disastrous. This game features two defenses ranked in the top-5 in EPA. And I suspect Cleveland defensive coordinator Jim Schwartz to have an exceptional gameplan in place to slow down Kyle Shanahan's offense. And the Browns have the talent at all three levels to limit Brock Purdy and the Niners. Unfortunately, with Walker under center I'm not sure San Francisco needs too many points to cover this game. So instead, I'll begrudgingly pass on the side and take a small shot on the under, as both defenses could dominate in a game that's projected to have winds between 16-and-30 MPH.

Pick: Under 36.5

-Matt Barbato

Panthers vs. Dolphins

The Panthers are going through their growing pains with this revamped team. Bryce Young hasn't been awful, but he's struggled in spots and the offensive line isn't giving him much help, as he's been sacked 12 times in four games. The Dolphins are the most explosive offense in the league. Tua Tagovailoa is leading the league in passing yards, Tyreek Hill is leading in receiving yards, and De'Von Achane is second in rushing yards, but unfortunately, he will miss some time with an injury. That will not matter, as Miami has so many weapons on offense, and they should be able to win over a win-less team convincingly.

Pick: Dolphins -13.5

-John Supowitz

Lions vs. Buccaneers

The Lions are on a three-game winning streak, thanks to solid offensive play. The Lions have scored at least 34 points in their last two games but have held opponents to 24 or fewer points in each of their last three games. Jared Goff has led the Lions to 394 yards per game. The entire offense is playing at a high level. They might even get Jahmyr Gibbs back in the mix this weekend. On the other hand, the Buccaneers don't look terrible on offense either, despite averaging 307.5 yards per game. They've played more complementary football and have enjoyed success to start the season. The defense has been bad against the run, allowing 94.8 yards per game. It doesn't look as bad on paper, but when good running teams start to rush against the Bucs, they'll find success. The Lions have earned 141 yards on the ground per game.

Pick: Lions -3

-Jason Radowitz

Colts vs. Jaguars

Anthony Richardson is out for at least four weeks with a shoulder injury. Therefore, Gardner Minshew will get the start for the Colts moving forward. He's one of the better backups in the NFL, so the Colts can still win games. The defense has allowed 401.2 yards per game, including 119.2 yards on the ground and another 282 yards in the air. Indianapolis' secondary hasn't looked good, and the missed tackles continue to pile up. If the secondary struggles on Sunday against Trevor Lawrence, the Jaguars will pile it on with points. They scored 31 in a 31-21 win over the Colts in Week 1. Meanwhile, the Colts have averaged over 350 yards per game, while the Jaguars' defense has given up 353.2 yards. Jacksonville isn't as good against the run this season. The secondary has actually performed well. However, the pass rush is ineffective for the Jaguars.

Pick: Over 44

-Jason Radowitz

Saints vs. Texans

New Orleans has something the Texans don't. It's not a quarterback. C.J. Stroud has been terrific for Houston. It's actually not on the offense. It's the defense. The Texans don't have a defense of the same quality as the Saints. The Saints have allowed just 289.2 yards per game, while the Texans have given up 345.8 yards. There's really no weakness with the Saints on defense. But the Texans are terrible against the run and continue to miss tackles at a very high rate. Derek Carr will have the guys ready on offense. Alvin Kamara could also have a significant game on the ground.

Pick: Saints -1.5

-Jason Radowitz

Patriots vs. Raiders

The Patriots have looked absolutely terrible over the last two weeks. They've lost by a combined score of 72-3 to Dallas and New Orleans. Sports radio talk is going crazy. The Patriots fans want Mac Jones benched and Bill Belichick to get fired. So, of course, the Patriots will rebound and win this week. I truly believe it. Both offenses have averaged about 300 yards per game. But the New England defense has looked better against the run. With that said, I'll take the Patriots and the points. This is one of the few games the Patriots can win this year. Let's benefit from it.

Pick: Patriots +3

-Jason Radowitz

Cardinals vs. Rams

The Cardinals have been a sneaky-good covering team early in the season. The last two weeks have sent them back down to earth and they’re looking like the team everyone thought they would be. Squarely towards the worst in the league with a 30th ranked pass defense per DVOA. This could spell trouble against a Rams offense that is fully operational now with WR Cooper Kupp back from injury. Adding Kupp to a passing game that was thriving with breakout star WR Puka Nacua will make Matthew Stafford even a larger threat. I don’t think the Cardinals will be able to do enough to slow down the Rams and LA should coast to victory with a cover.

Pick: Rams -6.5

-Ryan Rodeman

Eagles vs. Jets

Last week, the New York Jets beat the Denver Broncos by putting the child locks back on Zach Wilson and relying on Breece Hall and the running game. But I suspect against the Philadelphia Eagles, we'll see a more aggressive gameplan for Wilson, similar to what we saw two weeks ago against the Chiefs. Wilson is averaging just 2.3 seconds in the pocket over the last two weeks, part of that being by design and part of that being because New York's offensive line can't protect him. Now the shoddy Jets offensive line will be without its best blocker, Alijah Vera-Tucker, against an Eagles front that generates pressure at the fifth-highest rate in the league. While I don't see New York putting up many points, I also trust the Jets defense to hold up against a dynamic Eagles attack. While taking the home dog is tempting, I'm more confident in the under.

Pick: Under 41

-Matt Barbato

Giants vs. Bills

This is admittedly not a game I’m sprinting to bet, as it’s just so ugly. And while the Giants are an abomination in every sense, they have a scheme that has flustered Allen historically as well as a ton of familiarity in head coach Brian Daboll, who will surely do everything possible to put on a good showing against his old team.

While I don’t love this bet by any means, I suspect the Bills come out of the gates a bit sluggish after their loss across the pond last week. The injuries on defense will also add up at some point, and if Barkley is back he’s certainly capable of exposing this front seven that will be missing DaQuon Jones and Matt Milano up the middle.

Ultimately, I don’t think the drop off between Taylor and Jones is all that significant, and would begrudgingly lean the Giants at this number.

Pick: Giants +15.5

-Matt Barbato

Whether you're new to sports betting or a betting pro, our Sports Betting Strategy and Advice page is for you. You can get started with our 101 section - including 10 Sports Betting Tips for Beginners - or head to more advanced strategy - like Key Numbers When Betting Against the Spread - to learn more.