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NFL Week 6 Same Game Parlays & Picks (2025)

Author image by Dan Servodidio | @dan_servodidio | Oct 11, 2025
Author image by Dan Servodidio | @dan_servodidio | Oct 11, 2025
NFL Futures Bets: Offensive Rookie of the Year (2025)

NFL Week 6 is here, and it’s time to lock in some best bets and props before the games kick off. Picking matchups against the spread (ATS) and betting on the over/under is more commonplace, but a same game parlay (SGP) gives us even more added action. Let’s find some plus-money NFL Week 6 same game parlays for every game on the Sunday afternoon slate.

Keep in mind the odds below are accurate as of writing, but are always subject to change up until kickoff. Keep track of any of the latest NFL injury news and odds movement before locking in any of these SGP bets. Without further ado, let’s dive into the best NFL Week 6 same-game parlay bets.

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    Best NFL Week 6 Same Game Parlays 

    (Odds courtesy of DraftKings Sportsbook unless otherwise noted)

    Arizona Cardinals at Indianapolis Colts

      As of this writing, Kyler Murray's status is up in the air. He's questionable after suffering a foot injury last week. Veteran Jacoby Brissett would get the start in place of Murray. Whether he plays or not, let's still take the over on Marvin Harrison Jr.'s receiving yards. 

      Much has been made about Harrison's struggles to begin the season. Yet, this is still an elite talent who just had 98 receiving yards last week. He and Murray have improved their connection, too. If Brissett starts, he'll also likely look Harrison's way often. The matchup is favorable as the Colts have allowed the fourth-most receiving yards to wide receivers. 

      On the Indianapolis side of things, Tyler Warren should bounce back after being "held" to 44 yards last week. The rookie tight end still has a team-high 307 yards on the year as a favorite target for Daniel Jones. He's had 70+ yards in three of five games and can get back to that production in a favorable spot. The Cardinals are allowing the fifth-most receiving yards per game to tight ends. 

      This next prop is not for the faint of heart. Jonathan Taylor looks like one of the best running backs in the league right now. Yet, his rushing yards could be capped a bit this week. The Cardinals are allowing just 3.9 yards per carry (7th in NFL) and 92.4 rush yards per game (8th). The Arizona run defense is better than you'd think. Meanwhile, Taylor has been held under 80 yards in three of his five games. 

      Parlay Odds: +445

      Los Angeles Chargers at Miami Dolphins

        If you play fantasy football, then you know all about the Hassan Haskins vs. Kimani Vidal debate. With Omarion Hampton now joining Najee Harris on the shelf, plenty of carries are up for grabs in the Chargers' backfield. Honestly, we don't know how the workload will be split up between Haskins and Vidal. 

        Let's take a shot on Haskins going over his low rushing yards prop, though. He has a slightly bigger build than Vidal, which could translate to more early-down work. Vidal, meanwhile, could be used more in the third-down role. Plus, it's worth noting that Haskins had been the third RB active over Vidal earlier this season when Harris was healthy. 

        The matchup is a glorious one. Miami has the worst run defense in the NFL, allowing 174.2 rushing yards per game. One or both of Haskins/Vidal will go over their props in this spot. We'll side with Haskins as he should get more carries on first and second down. With that in mind, back him to get 12+ carries at some valuable odds. 

        Let's also take the Over on Justin Herbert's rushing yards. The Dolphins are allowing the fourth-most rush yards to quarterbacks this year. Four of five opposing QBs have run for 25+ yards against Miami. Add Herbert to that list this week. He's run for at least 24 yards in four of five games so far while showing a larger willingness to make plays with his legs. 

        Parlay Odds: +480

        New England Patriots at New Orleans Saints 

          Although Juwan Johnson has underperformed in the past two games, let's go right back to his receiving yards prop. The tight end is still a favorite target for Spencer Rattler in the Saints' passing game. His 35 targets and 24 receptions trail only Chris Olave for the team lead so far. 

          Johnson has been limited in practice this week with an ankle injury, but it looks like he's trending towards playing. He'll face a Patriots defense that's allowing the second-most receiving yards per game to tight ends. It's good matchup for Johnson, who had at least 49 yards in each of the first three games of the year. 

          On the Patriots' side, Drake Maye should be active enough with his legs to go over his rushing yards prop. The Saints are allowing 29.2 rush yards per game to opposing quarterbacks (seventh-most in NFL). The defense has faced three dual-threat QBs so far and allowed 55 yards to Jaxson Dart, 45 yards to Josh Allen, and 38 yards to Kyler Murray. 

          As for Maye, he's averaging just 22 rushing yards per game. Yet, he did run for 31 and 45 rushing yards in two games. Last year, Maye had at least 24 rushing yards in nine different games. Look for him to scramble enough to get to 25+ yards in this matchup. 

          Let's finish this parlay off with Stefon Diggs, who just exploded for 146 yards on 10 receptions in last week's upset of Buffalo. He also put up 101 yards on six catches in the game prior. Maye is looking Diggs' way plenty right now, so let's ride that connection. He now has 50+ yards in three of five games, and he's now done so in eight of his last 11 contests going back to last year. 

          Parlay Odds: +435 

          Cleveland Browns at Pittsburgh Steelers

            The situational spot in this AFC North rivalry heavily favors Pittsburgh this week. The Steelers are coming off a bye after playing in Ireland back in Week 4. They'll look to get back on track after losing that game to Minnesota. Meanwhile, the Browns just played in London and lost to the Vikings. Now they have to turn around and play on the road against a divisional opponent without a bye in between. 

            Let's take the Steelers to get the comfortable home win. The home team has seven straight games in this rivalry, by an average of nine PPG as well. Meanwhile, Browns head coach Kevin Stefanski is an ugly 11-21 ATS against AFC North opponents. Cleveland has a strong defense, but the offense is in a rough spot with rookie Dillon Gabriel making his first road start. 

            Speaking of Gabriel, he should be looking David Njoku's way often this week. In last week's game, Njoku was Gabriel's favorite pass-catcher with six receptions for 67 yards and a TD on nine targets. A tight end is usually a rookie quarterback's best friend, especially a veteran one like Njoku. The Steelers are allowing the 10th-most receiving yards per game to tight ends (62.5). 

            On the Pittsburgh side, Jaylen Warren is expected to return after missing one game. The running back should go right back to having a pass-catching role in the offense. Warren is averaging 47.3 receiving yards per game with at least 22 yards in each. With Warren out last game, Kenneth Gainwell had 35 receiving yards. We know Aaron Rodgers likes throwing to his running backs and Warren can step back into that role now that he's healthy. 

            Parlay Odds: +490

            Dallas Cowboys at Carolina Panthers

              Chuba Hubbard is out again for Carolina, thrusting Rico Dowdle into the lead back role once more. Dowdle exploded for 206 rushing yards and 28 receiving yards on 26 total touches last week as the Panthers' RB1. Another big game could be coming against the Cowboys' bottom-tier defense. 

              We could look at Dowdle's rushing yards prop, but let's grab the receiving yards line instead. The Cowboys are allowing a league-high 59.8 receiving yards per game to opposing running backs this season. The scheme welcomes underneath targets for RBs, and Bryce Young should dump it off to Dowdle enough here. He showed pass-catching chops last year with Dallas and can easily go for 16+ yards here. 

              Tetairoa McMillan continues to see a ton of targets as a favorite option for Young in the Panthers' passing attack. In fact, McMillan has at least eight targets in every game this season while averaging 70.2 receiving yards per contest. He now faces a Dallas defense that's allowing the most receiving yards per game to wide receiviers (188.8). McMillan will see most of that production with his locked-in role. 

              Over to the Cowboys offense, where tight end Jake Ferguson could have a big game. The Panthers have allowed the most receiving yards and the sixth-most receptions to opposing tight ends this season. It's a prime matchup for Ferguson, who's averaging 62.3 yards per game over the past four contests. He also has 7+ catches in four straight as a top target for Dak Prescott, especially with CeeDee Lamb sidelined. 

              Parlay Odds: (+425 at BetMGM Sportsbook)

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              Seattle Seahawks at Jacksonville Jaguars

                The Seahawks and Jaguars were both involved in coin-flip games last week, but they came out on opposite ends. Seattle lost on a field goal as time expired en route to a 38-35 defeat to Tampa Bay. Meanwhile, Jacksonville pulled off the home upset over Kansas City on Monday night, thanks to an improbable Trevor Lawrence scramble touchdown in the final minute. 

                Let's back the Seahawks to right the ship and get this road victory. The offense is averaging 29.2 PPG (5th in NFL) while ranking in the top 10 in total yards per game. The Seattle attack now faces a Jaguars defense that just gave up 476 total yards to the Chiefs in a back-and-forth, high-scoring thriller. This is also a prime let-down spot for Jacksonville against a non-conference opponent after upsetting KC at home. 

                Jaxon Smith-Njigba enters this game second in the NFL with 534 receiving yards, trailing only Puka Nacua. The third-year wideout is terrorizing defenses on a weekly basis, averaging 106.8 yards per game. He now faces a Jaguars secondary that's allowing the 11th-most receiving yards per contest to wide receivers. It's a very beatable matchup and Smith-Njigba has at least 79 yards in every game thus far. Getting to 80+ is a low bar for him right now. 

                On the Jags' side of things, let's look at Travis Etienne's receiving yards line. The Jackonville tailback only has 41 total receiving yards through five games, but this is a matchup where he should be used more in the passing game. The Seahawks are allowing 58.4 receiving yards per game to opposing RBs, the second-most in the NFL. Etienne has 15+ receiving yards in eight games last year and 14 games in 2023, so we know the pass-catching skillset is there. 

                Parlay Odds: +490

                Los Angeles Rams at Baltimore Ravens

                  The Rams are sizable road favorites over the Ravens in this game. It makes sense with Lamar Jackson still sidelined and how good Los Angeles has looked this season. Instead of worrying about the spread or total, let's grab a trio of player props. 

                  The expected game script and matchup both point to a big Kyren Williams game. The Rams' running back will face a Ravens defense that's allowing the fourth-most rushing yards per game (146.4). The unit is also dealing with notable injuries on all three levels. The Texans just ran for 167 yards on 5.1 yards per carry against Baltimore. 

                  Williams is averaging 73.6 rushing yards per game this year, with at least 65 yards in every contest. He's yet to have a 100-yard game, but it feels like that's coming. This could be the matchup. Either way, he can at least go over the rushing prop here while likely get plenty of carries with the lead in the second hald. 

                  Let's keep it going with two more Rams' props against this struggling Baltimore defense. This is also a favorable matchup for Davante Adams. The Ravens are giving up the third-most receiving yards per game to wideouts this year and have key injuries in the secondary. Both Adams and Puka Nacua can rack up yards as they dominate the target share. Adams is averaging 71.4 yards per game with 50+ in each. 

                  Plus, maybe Adams is on the receiving end of a long completion or two from Matthew Stafford. The Ravens are also allowing the second-most passing yards per game, while giving up 8.0 air yards per target (fourth-most). The Rams, meanwhile, lead the league in air yards per attempt at 8.5. Stafford has a completion of at least 36 yards in every game so far, and a 40+ yard completion seems likely in this matchup. 

                  Parlay Odds: (+360 at BetMGM Sportsbook)

                  Tennessee Titans at Las Vegas Raiders

                    Ashton Jeanty had a slow start to the season, but he's woken up over the past two games. The Raiders' rookie running back had 138 rushing yards in Week 4 and then 109 total yards last week (67 rushing). Jeanty and the Las Vegas run game have started to find a rhythm. 

                    Let's back Jeanty to keep it going at home in a favorable matchup this week. The Titans are allowing 146.8 rushing yards per game (third-most in NFL) and 5.0 yards per carry (fifth-most). They just gave up 168 yards and 5.8 yards per carry to Arizona, despite that backfield missing its two top RBs. It's a good spot for Jeanty to have another productive day. 

                    The Raiders' pass defense is allowing the fourth-most receiving yards per game to opposing wideouts this season (168.6). So, let's take a pair of Tennessee wide receivers to go over their yards props this week. Both Calvin Ridley and Elic Ayomanor can connect with Cam Ward enough in this matchup. 

                    Ridley has been relatively quiet this season, but he just broke out for 131 receiving yards last week. He also saw a season-high 10 targets. Hopefully, that gets him going as he and Ward build on their rapport. As for Ayomanor, he's averaging 33.8 receiving yards per game as the solidified No. 2 wideout. He's exceeded 30 yards in three of five games, and he can do it again this week. 

                    Parlay Odds: +470

                    Cincinnati Bengals at Green Bay Packers

                      Coming out of the bye, Josh Jacobs finds himself in a dream matchup with a very favorable game script. It sets up perfectly for him to rack up rushing yards. The Bengals have allowed the second-most rushing yards to opposing running backs this season. The defense just gave up 119 combined yards to Jahmyr Gibbs and David Montgomery last week, and allowed 159 yards to Denvers' RB combo the game prior.

                      Plus, the Packers are double-digit favorites at home. They should cruise to the win, setting up Jacobs for plenty of second-half carries. The Green Bay lead back is averaging just 66.5 rush yards per game, but he does have 80+ in two of his four games. It's also encouraging that he's seeing 20 carries per contest so far. 

                      The Green Bay offense should also feature tight end Tucker Kraft this week. The Bengals are allowing 69.0 receiving yards per game to opposing tight ends this season (fourth-most in NFL). They're also giving up a league-high 9.8 targets per game to TEs. Meanwhile, Kraft comes in leading the Packers in receiving yards so far, while averaging 56.3 per game. 

                      We successfully faded Chase Brown's rushing yards last week, and we'll gladly do it again. The Bengals' lead back has struggled this season, averaging just 32 rushing yards per game and 2.5 yards per carry. He's yet to eclipse 50 yards in any game. Brown now faces a Packers defense that's allowing the fifth-fewest rushing yards per game to opposing RBs (68.3). Add in a likely negative game script on the road, and a Bengals offense that could be pass-heavy anyway with Joe Flacco now at quarterback, and Brown's rush attempts should be limited. 

                      Parlay Odds: +475

                      San Francisco 49ers at Tampa Bay Buccaneers 

                        Christian McCaffrey has been a pass-catching machine this season. He already has 39 receptions, 52 targets, and 387 receiving yards through five games. CMC is also averaging 77.4 receiving yards per game with game totals of 82, 92, 88, 52, and 73. The 49ers are using him a ton in the passing game with Brock Purdy out and a slew of injuries in the receiving corps.

                        San Francisco's star RB now gets a favorable matchup to keep the receiving production going. The Buccaneers are allowing the third-most receiving yards per game to opposing running backs (51.4). CMC getting to at least 50 yards through the air in this spot should be a layup. 

                        Let's also back the other running back in this game. Bucky Irving will be out again, so Rachaad White continues in the featured role. White had 71 total yards on 18 touches last week as the Bucs' starter. He should see enough carries and receptions to have another good performance this week. The 49ers have allowed 131 and 125 total yards to Kyren Williams and Travis Etienne in the past two games, respectively. 

                        Add Emeka Egbuka to the parlay as well. Chris Godwin has been ruled out, so Egbuka is back as the main wideout for Baker Mayfield. Even with Godwin playing recently, Egbuka put up 163 and 101 yards in the past two games. The 49ers have been vulnerable against slot receivers, and the Bucs may move the rookie back into that spot with Godwin sidelined again. 

                        Parlay Odds: (+400 at BetMGM Sportsbook)

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