At one point, it looked as if Arsenal could put it on cruise control and coast to a Premier League title. That's not the case anymore, as Manchester City has narrowed the gap to six points and still has a game in hand. With that said, the Gunners can quash any doubts this weekend if they pick up a result at the Etihad against the Citizens. Below, I'll dive into that headlining clash, as well as two others, from a sports betting angle. Here are my top Premier League Matchday 33 picks.
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Premier League Matchday 33 Picks & Preview (2026)
(Odds courtesy of DraftKings Sportsbook)
Tottenham Hotspur (+180) vs. Brighton & Hove Albion (+135), DRAW (+280) | O/U 2.5 (-145/+115)
We have thrilling storylines both at the top and bottom of the Premier League table. Toward the bottom, it's Tottenham Hotspur (7-9-16) that's trying to fend off relegation and stay at the top flight. You have to go back to 1991-92 to find the last time the Lilywhites were playing in the lower levels of English soccer. They'll host ninth-place Brighton & Hove Albion (12-10-10) on Saturday at 12:30 p.m. ET from Tottenham Hotspur Stadium in London.
I'll take the plus-money payout that comes with Brighton & Hove Albion to win on the road. The ninth-place club has been playing well, winning its last three league matches. Going back even further, the Seagulls are 5-0-1 in their last six, with the lone defeat being a 1-0 home loss to top-ranked Arsenal. It's safe to say they're in great form.
Meanwhile, Tottenham Hotspur has dropped two straight games, getting shut out in both defeats. They're also just 2-4-10 at home this season with a -10 goal differential (18:28). With their offense not finding success and their defense ranked 17th in goals allowed (51), you can start to see the case for an easy fade of the Lilywhites. Let's lock in Brighton & Hove Albion at plus-money.
Bet: Brighton & Hove Albion Moneyline (+135)
Manchester City (-115) vs. Arsenal (+330), DRAW (+260) | O/U 2.5 (-105/-120)
I briefly covered the title chase in the intro, but diving further, we see that Arsenal (21-7-4) enters the weekend with a six-point lead over second-place Manchester City (19-7-5). City does have a game-in-pocket to close the gap even further. At this juncture, DraftKings Sportsbook has the Gunners priced at -160 to win the English Premier League, while Pep Guardiola’s group sits at +125. Kick-off is scheduled for Sunday at 11:30 a.m. ET from Etihad Stadium in Manchester.
Manchester City is priced in the pick’em range to win this match, and I think that's fair. I'll go ahead and back them on the Moneyline at -115. I went back and looked at the head-to-head history between these clubs, and what stands out most to me is that Manchester City is unbeaten at home against Arsenal in the last 11 meetings. Dating back to 2016, the Citizens are 8-3-0 against them at the Etihad, outscoring the Gunners 26 to 8.
Even though Arsenal has been lights out defensively, I don't think it would be shocking to see Manchester City break through for a goal or two. They're first in home scoring with 36 goals, averaging more than three tallies per game this season. On the flip side, Arsenal is coming off a 2-1 home loss to Bournemouth last weekend, and you can also factor in potential fatigue from their deep Champions League run. I think there are enough variables here to warrant a bet on City at coin flip odds.
Bet: Manchester City Moneyline (-115)
Crystal Palace (+140) vs. West Ham United (+205), DRAW (+230) | O/U 2.5 (-115/-110)
The matchday wraps on Monday with an intriguing bottom-half showdown between 13th-place Crystal Palace (11-9-11) and 17th-place West Ham United (8-8-16). This weekend’s finale is slated for 3:00 p.m. ET from Selhurst Park in London.
I'm taking it to the prop sheet in this one, and I'm playing the ‘Both Teams to Score’ prop at -160 odds. Starting with West Ham United, they're coming off a 4-0 rout of lowly Wolverhampton Wanderers, and they've now scored one or more goals in 14 of their last 16 matches in all competitions. Crystal Palace is sound defensively, but the Eagles are also coming off a midweek fixture in the UEFA Conference League (2-1 loss at Fiorentina). This could easily be a letdown spot as they return to England, especially against a West Ham United side that's fighting for its Premier League life.
On the other side of the pitch, Crystal Palace should have no issues finding the back of the net. West Ham United has been abysmal defensively, ranking 18th in goals against (58) this year. Specifically, on the road, they've gone 4-4-8 and have allowed 29 goals in 16 matches. Palace is averaging two goals per match across its last four games in all leagues, and I think they'll manage to find a goal with their home crowd behind them. I like this one to land 1-1, or maybe 2-1 in favor of the hosts.
Bet: Both Teams to Score (-160)
