College Football Week 10 Early Picks & Predictions (2025)

The 2025 college football season has been a wild ride, with multiple coaching vacancies opening up at some of the premier blue blood programs. As we enter the final month of the regular season, the stakes get higher for teams in contention to win their conference or qualify for the 12-team College Football Playoff.

My College Football Week 9 Early Picks & Predictions fell flat, settling 0-3. Oklahoma couldn’t contain Ole Miss and its explosive offense, losing outright at home as a -4.5 point favorite. Missouri held its own against Vanderbilt’s top-ten scoring offense but fell an inch short of tying the game to force overtime, losing 17-10 and failing to cover +3.0. Finally, South Florida -3.5, which held a 31-17 lead in the fourth quarter, got shutout by Memphis, leading to a 34-31 loss.

I’ve found three of my favorite plays to bet in Week 10 based on early line movement. Follow me on X @Matt_MacKay for additional betting analysis and free picks.

College Football Week 10 Picks & Early Line Movement

(Odds courtesy of DraftKings Sportsbook)

Georgia Tech (8) vs. NC State  

Georgia Tech QB Haynes King has been a dynamic playmaker with his legs. The Yellow Jackets rank 25th in points per game, averaging 36.0, thanks to King’s elite rushing ability.

Georgia Tech is 8-0 and will play its fourth road game of the season against NC State. The Wolfpack struggle on defense, surrendering five rushing touchdowns across the last two games, while also giving up over 340 passing yards during this stretch.

NC State is 1-3 against ACC opponents. They have home field advantage in their favor, otherwise, there’s no reason to fade Georgia Tech as a touchdown favorite. The lines have already moved -2.0 in favor of the Yellow Jackets at -6.5, so let’s lay this number with Georgia Tech in a prime-time road game.

Pick: Georgia Tech -6.5 (-110)

 Vanderbilt (9) vs. Texas (20)

Vanderbilt and Texas are both coming off hard-fought, emotional wins in Week 9. Vanderbilt QB Diego Pavia remains a top-five Heisman Trophy favorite, despite struggling to account for more than 150 total yards of offense.

Pavia and the Commodores hit the road for an early noon ET kickoff against the No. 20 Texas Longhorns. QB Arch Manning suffered a concussion during the Longhorns’ wild comeback win on the road against Mississippi State. His availability is questionable for this game.

Texas’ defense had a rare poor outing in Week 9, giving up five passing touchdowns and over 380 passing yards to the Bulldogs. Going back home could help them bounce back, as Texas has played four straight games on the road or at a neutral site.

Line movement has gone in favor of Vanderbilt. The Commodores are now +1.5 instead of +3.5 for their fourth road game of the year. Vanderbilt is very good at stopping the run, allowing three total rushing touchdowns and a stingy 3.5 YPC.

Defending the pass has been more suspect. However, with Manning potentially sitting out in this SEC tilt, there’s value on the point total.

Two top-25 scoring defenses means we’re going to invest in under 45.5 total points. The point total hasn’t moved in either direction, so this feels like the best play to make in this game.

Pick: Under 45.5 (-115)

Cincinnati (17) vs. Utah (24) 

We’re going to grab action on a late-night kickoff in a marquee Big 12 matchup when the Utah Utes host the Cincinnati Bearcats. Both teams have been throttling opponents, excluding Utah’s 24-21 loss to undefeated BYU in Week 8.

Utes QB1, Devon Dampier, didn’t even play during the team’s 53-7 rout of Colorado in Week 9. He should be fully healthy for Cincinnati’s 28th-ranked scoring defense.

Cincinnati QB Brendan Sorsby has been playing lights out for the Bearcats. He’s thrown 20 touchdowns and only one interception, with a 65 percent completion rate and over 1,800 passing yards.

Utah’s pass defense is going to be a massive test for Sorsby. The Utes are holding opposing quarterbacks to a 52.6 percent completion rate and five total passing touchdowns. Cincinnati’s best path to a win is through its run game, which has been extremely productive.

The Bearcats’ offense is a top-tier unit, averaging 5.9 YPC and 16 rushing touchdowns. It’s only their third true road game of the season, but Cincinnati is riding a seven-game winning streak after losing their season opener at a neutral site against Nebraska.

Line movement has gone in favor of Utah, moving from -5.5 to -7.5. This is too many points and undervalues Cincinnati’s offense.

Let’s take the points with Cincinnati +7.5 and back the more explosive offense to cover as a touchdown underdog on the road in Salt Lake City, Utah.

Pick: Cincinnati +7.5 (-115)