The MLB season is officially underway. After a jam-packed Opening Day slate on Thursday, let’s do it all again. We have a smaller slate of games today. Even so, it’s time to dive into the matchups and pick out some winning MLB bets. This article will break down a pair of MLB same game parlays (SGPs) that feature player props and juicy plus-money odds. Note that all odds and betting lines are accurate as of this writing, but subject to change. Good luck.
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Friday’s Best MLB Same Game Parlays
(Odds courtesy of DraftKings Sportsbook)
Los Angeles Angels vs. Houston Astros
- Leg 1: Yusei Kikuchi 2+ Earned Runs Allowed (-238)
- Leg 2: Yordan Alvarez Over 1.5 Total Bases (-101)
- Leg 3: Mike Burrows 6+ Strikeouts (-134)
This American League West matchup features Yusei Kikuchi starting for Los Angeles and Mike Burrows on the mound for Houston. Our same-game parlay is based around fading one of those pitchers, in multiple ways, while backing the other in a favorable spot. Let's break it down.
Yusei Kikuchi had a shaky 3.99 ERA and 1.42 WHIP last year for the Angels. The left-hander also had his worst strikeout rate (22.5%), batting average allowed (.259) and xFIP (4.28) since his rookie season. Kikuchi will have his hands full today with a Houston offense that ranked in the top 10 in wOBA, wRC+, strikeout rate and OPS versus lefties a season ago. Plus, the Angels starter struggled to a 5.04 ERA on the road in 2025.
One of the Astros to watch in this matchup is Yordan Alvarez. He's fully healthy heading into the season, which means he's among the league's most dangerous hitters. Alvarez brings in favorable splits against the left-handed Kikuchi. Last year, Houston's designated hitter batted .344 with a 1.103 OPS versus southpaws. In 2024, he hit .362 with a 1.028 OPS against lefties. Plus, Alvarez is 10-for-28 (.357) with three homers and three doubles in his career against Kikuchi.
After being traded from the Pirates to the Astros this offseason, Mike Burrows is now viewed as a breakout starting pitcher candidate. The right-hander was excellent in spring training, posting a 1.50 ERA over five outings with 17 strikeouts across 18 innings. Houston has reportedly made some mechanical changes to Burrow's delivery, leading to increased velocity and a new sinker. He could rack up strikeouts against an Angels lineup that had a league-worst 27.1% strikeout rate versus righties a year ago.
Parlay Odds: +320
Cleveland Guardians vs. Seattle Mariners
- Leg 1: George Kirby 7 or Fewer Hits + Walks + Earned Runs Allowed (-190)
- Leg 2: Chase DeLauter 1+ Hits + Runs + RBIs (-180)
- Leg 3: Gavin Williams Over 3.5 Hits Allowed (-145)
After posting a 4.21 ERA last year, George Kirby could be primed for a bounce-back season. The Mariners starter still put up a 3.37 FIP and 3.25 xFIP last year, which is encouraging that a resurgence may be coming. Notably, the righty allowed two runs or fewer in nine of his final 12 starts in the regular season. Let's count on him beginning this season strong.
Cleveland was a bottom-tier offense versus right-handed pitching last season, with a .296 wOBA (27th) and a .227 batting average (29th) in the split. Kirby can take advantage of this matchup, especially at home. Kirby was a lot better at home in 2025, with a 3.12 FIP and .275 wOBA allowed, than on the road (5.16 ERA, .327 wOBA). He also sports a 3.07 ERA in his career when pitching in Seattle. Plus, Kirby ended spring training on a high note, with a 2.77 ERA over his final three outings.
Though we're backing Kirby in this parlay, that doesn't mean Guardians rookie Chase DeLauter can't be involved. DeLauter showed out in a big way on Thursday for his MLB regular-season debut. He went 3-for-5 with a pair of home runs. It looks like DeLauter has carried over a scorching hot spring into the season. DeLauter hit .459 with a 1.373 OPS across 14 games in spring training. We never want to take too much stock in March numbers, but he might be the real deal.
On the other side, Gavin Williams is worth fading on the road tonight. The Cleveland starter had an impressive 3.06 ERA last year, though his 4.39 FIP and 4.29 xERA tell a slightly different story. Notably, Williams has a shaky 5.14 FIP on the road last season, with his strikeout rate (20%) way down compared to outings in Cleveland (29%).
Williams enters the regular season following an up-and-down spring. He posted a 4.58 ERA across five outings and got rocked for five runs on seven hits by the Cubs in one of those starts. We may see the right-hander give up some hits on the road here. The Mariners were a top-10 offense versus right-handed pitching last year, with a .324 wOBA and 114 wRC+ in the split.
Parlay Odds: +355
