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NCAA Tournament Picks: Sweet 16 Parlay (2026 March Madness)

NCAA Tournament Picks: Sweet 16 Parlay (2026 March Madness)

The hardest part about betting on March Madness isn’t necessarily deciding what to bet on, but what not to bet on, because you only have so much money in your bankroll. But you believe in your research and analysis and don’t want to pass on these markets-and you don’t have to. Why not? Because you can combine them into a Sweet 16 Parlay! Here are a few of our top NCAA Tournament picks for the Sweet 16.

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NCAA Tournament Picks: Sweet 16 Parlay

(Odds courtesy of FanDuel Sportsbook)

Purdue vs. Texas

Leg #1: OVER 77.5 Points at -120 (Thursday)

Texas is in over its head. The Longhorns have been a great story, fighting their way from the First Four to the Sweet 16 as a No. 11 seed. Purdue is going to make the Texas defense look exactly like it is, the most inefficient defense remaining in the Tournament.

Purdue has the most efficient offense in the country (No. 1 in KenPom offensive efficiency rankings). The Boilermakers have averaged 82.2 points per game this season and should easily go OVER that number and the TOTAL.

Arkansas vs. Arizona

Leg #2: OVER 166 Points at -110 (Thursday)

Here we have two of the best offenses in the country: one that scores 90 points per game (Arkansas) and the other 86 points per game (Arizona). Both also happen to be two of the most efficient offenses in the country (according to KenPom), with Arizona No. 4 and Arkansas No. 5.

However, the Wildcats also rank third in the nation in defensive efficiency. As for the Arkansas defense, it has allowed 80.3 points per game this season. Arizona’s offense will have no trouble exploiting it. Arkansas will have a harder time scoring against the Wildcats defense, but the Razorbacks will score enough to send the final score OVER this TOTAL.

Michigan vs. Alabama

Leg #3: Michigan -10 at -110 (Friday)

Alabama has one of the most prolific scoring offenses in the nation, but the reason for its eventual downfall is not too hard to figure out: its defense. It allows 82+ points per game, is ranked No. 60 in the KenPom rankings, and is ranked No. 347 in the NCAA points allowed stats. Michigan’s defense ranks No. 6 in efficiency. It will not shut the Tide down, but it will slow it down enough for Michigan to cover.

Duke vs. St. John’s

Leg #4: Duke -6.5 at -110 (Friday)

The Blue Devils have the most efficient defense in the country and a top-10 offense. St. John’s has a top-10 defense (No. 8) but ranks No. 42 in offensive efficiency. The Red Storm score a respectable 81.1 points per game, but are not great shooters. They do so by playing an up-tempo game and attempting more baskets. Duke’s defense is not going to give them the opportunity.

The Blue Devils will control the pace and limit the number of possessions, making it almost impossible to make up for a lack of accuracy. Red Storm head coach Rick Pitino will keep St. John’s in it for as long as possible, but Duke will eventually pull away.

Parlay Odds: +1126 - A $100 wager will result in a $1226 payday, your stake plus $1126 in winnings.

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