The NFL is still waiting on a Monday Night Football doubleheader to close out Week 6, but it’s time to look ahead to Week 7. We’re on a mission to find value in these early lines to assemble a pair of winning NFL parlays to bet on this upcoming Week 7 slate.
Notable Week 7 byes include the Buffalo Bills and Baltimore Ravens. Big games include the Los Angeles Rams vs. Jacksonville Jaguars in the NFL London Games matchup, as well as Philadelphia Eagles vs. Minnesota Vikings, Indianapolis Colts vs. Los Angeles Chargers, and Tampa Bay Buccaneers vs. Detroit Lions.
We finally hit a play in my NFL Parlays & Picks: Best Bets for Week 6 (2025) edition, cashing an Indianapolis Colts and Seattle Seahawks moneyline parlay at +165 odds. We came close to a 2-0 outing with my totals parlay. However, the New England Patriots and New Orleans Saints’ 45.5-point total wound up going under, with only six points scored in the second half.
Follow me on X at Matt_MacKay_ for more NFL betting analysis and free picks.
Get instant alerts when a line reaches your target via the BettingPros App >>
NFL Early Week Parlays: Week 7
(Odds courtesy of FanDuel Sportsbook)
Parlay 1 (+208)
Leg 1: Los Angeles Rams Moneyline (-154)
The Los Angeles Rams have cost us a parlay before but that doesn’t mean we’re going to hold a grudge. Head coach Sean McVay and QB Matthew Stafford are in a strong rhythm, although star wideout Puka Nacua did briefly exit the game against Baltimore with a foot injury before making a return.
The Rams are the latest team headed overseas to play in the NFL London Games series, facing the 4-2 Jacksonville Jaguars. The Jaguars just got shut down at home by Seattle in Week 6, losing 20-12.
Los Angeles didn’t put up ballistic numbers on offense in a soft matchup against Baltimore’s struggling defense. Ultimately, Stafford didn’t need to be superman, allowing the offense to churn out production on the ground, while the Rams’ defense bottled up the Ravens’ short-handed offense during a 17-3 road win.
Jacksonville’s run defense is stout but its pass defense has struggled in 2025. The Jaguars are allowing 5.6 yards per play, which is a bottom-12 metric. Stafford’s going to have his way against this defense and McVay won’t allow one of his former coaches, Jacksonville head coach Liam Coen, to beat him in their first head-to-head matchup.
Leg 2: New Orleans Saints vs. Chicago Bears – Over 45.5 (-115)
Neither the New Orleans Saints or Chicago Bears have played well on defense in a consistent fashion this season. The Bears are horrendous against the run and pass, allowing a league-worst 6.1 YPC and 7.2 net yards gained per pass attempt, ranked 30th in the NFL.
The Saints haven’t fared much better. New Orleans couldn’t handle Drake Maye at home in Week 6, allowing 261 passing yards and three touchdowns to New England’s second-year quarterback. Now, the Saints hit the road and go to Chicago, playing a Bears offense that has logged 21 or more points in every game played.
The Bears are 3-1 toward the point total over in 2025, while the Saints are 3-3. New Orleans could easily be 5-1 on the point total over, except their offense has sputtered in the second half with QB Spencer Rattler on multiple occasions.
Points should be abundant for both offenses in this NFC outing at Soldier Field. Caleb Williams is playing with confidence under new head coach Ben Johnson. Rattler has begun to show competency within head coach Kellen Moore’s offense, frequently playing from behind and being forced to air out the football.
Let’s cheer for points between the Saints and Bears. Bet over 45.5 total points at -115 for the second leg of this early Week 7 NFL parlay.
Parlay 2 (+242)
Leg 1: Indianapolis Colts +1.5 (-120)
The Indianapolis Colts are a wagon right now. QB Daniel Jones has revived his career and legacy with his new team, leading the Colts on a fourth quarter comeback to beat Arizona 31-27 in Week 6.
Indianapolis is 5-1 and could easily be 6-0, if not for a few self-inflicted wounds against the Rams. The Colts are getting +1.5 on the point spread against the Los Angeles Chargers, returning to SoFi Stadium, which was the site of their lone loss.
Justin Herbert and the Chargers’ offense needed a final minute drive to beat a one-win Miami Dolphins team in Week 6. Indianapolis’ defense is notably better than Miami, so Herbert won’t be able to easily chip away at multiple deficits like he did on Sunday at Hard Rock Stadium.
Getting a one-loss team as an underdog definitely feels a bit fishy. However, the Chargers have one of the worst run defenses in the league and will now face Colts RB Jonathan Taylor, who has a 5.1 YPC and six rushing touchdowns this season.
The Colts are one of seven teams with a 4-2 ATS record in 2025. Let’s continue betting on Indianapolis and take the point with them as a +1.5 underdog on the road against the Chargers in Week 7.
Leg 2: New York Giants vs. Denver Broncos – Under 40.5 (-115)
Jaxson Dart and Cam Skattebo have unlocked a new level of swagger and confidence within the New York Giants’ franchise. The rookie tandem just blew out the Philadelphia Eagles on Thursday Night Football as a touchdown underdog. Now, New York prepares for a tough tilt against a Denver defense ranked second in total points allowed (84) this season.
The Giants’ defense hasn’t been good, allowing 5.1 YPC and 144 total points. These are both bottom-tier metrics amongst defensive units in 2025. However, New York is fairly good at stopping the pass, ranked 15th in net yards gained per pass attempt and seven total passing touchdowns, which puts them in the top half of the league.
Denver’s offense only mustered a handful of points during a 13-11 win against a bad New York Jets defense in London. Now, Broncos QB Bo Nix will need to use his legs and feed RB J.K. Dobbins carries to rattle off a third straight win.
Denver likes to establish the run and chew clock. Expect long drives that may stall out in the red zone due to the Giants’ pass defense. The Broncos are 5-1 on the point total under this season, while the Giants are 4-2.
We’re going to bet under 40.5 total points in this Giants vs. Broncos matchup on Sunday’s late afternoon slate.
Subscribe: YouTube | Spotify | Apple Podcasts | iHeart | Castbox | Amazon Music | Podcast Addict | TuneIn