The San Francisco 49ers have mounted two great comebacks this postseason to earn their spot in the Super Bowl.
However, they'll need a fast start on Sunday. The Kansas City Chiefs defense is ranked in the top five statistically in most major categories. If the 49ers fall behind against them, they may have a hard time coming back.
So, what should we expect of their players in this game?
Here are the best PrizePicks plays for the San Francisco 49ers in the Super Bowl.
Our PrizePicks Cheat Sheet helps bettors by comparing lines from PrizePicks vs. our weekly NFL projections >>
The San Francisco 49ers have mounted two great comebacks this postseason to earn their spot in the Super Bowl.
However, they'll need a fast start on Sunday. The Kansas City Chiefs defense is ranked in the top five statistically in most major categories. If the 49ers fall behind against them, they may have a hard time coming back.
So, what should we expect of their players in this game?
Here are the best PrizePicks plays for the San Francisco 49ers in the Super Bowl.
Our PrizePicks Cheat Sheet helps bettors by comparing lines from PrizePicks vs. our weekly NFL projections >>

San Francisco 49ers Super Bowl PrizePicks
If you want to play it safe, take Christian McCaffrey to score at least one touchdown. However, the odds for that prop are worse than the typical odds available at PrizePicks. Therefore, we recommend taking a bit of a risk and getting much better odds for McCaffrey to score at least twice.
The Chiefs are the best defense he will have faced to this point, but that doesn't mean the 49ers aren't going to score at all. Including the postseason, McCaffrey has combined for 25 touchdowns this year. He has seven multi-score games, including both of his postseason performances. Whether the 49ers fall behind or play with the lead, McCaffrey is their guy. He's going to prove that once again on Sunday.
If the 49ers fall behind by two scores, this could be a bad play. However, everything we've seen this season indicates that Brock Purdy will go under this number. The Chiefs have held opponents to just 181.5 passing yards per game this season. They held Tua Tagovailoa and Josh Allen in their first two playoff games to under 200 passing yards each.
Last week, Lamar Jackson threw for 272 yards, but the Baltimore Ravens were playing from behind for nearly the entire game. Purdy will have his hands full against this great secondary. Even if he starts to compile yards late in the game, it's unlikely he'll barely cross this threshold as he did against the Detroit Lions and Green Bay Packers, two teams with significantly worse defenses than the Chiefs.
Deebo Samuel entered the NFC Championship with a shoulder injury. He quickly put all concerns to rest, finishing with eight catches for 89 yards. Samuel is the most important player in this passing game, and we expect Kyle Shanahan to draw up some plays that allow for easy throws between Samuel and Purdy early.
Samuel may not hit his yardage total, as we've already discussed with how good the Chiefs' defense is. However, it would be very surprising to see the 49ers go away from him even if things don't work early. Brandon Aiyuk finished the year ahead of Samuel in most receiving categories, but the 49ers went to Samuel in the conference championship when they needed plays. Look for that again in the Super Bowl.
Make sure to check out our other best bets for Wednesday:

Phil Wood is a featured writer at BettingPros. For more from Phil, check out his archive and follow him @Phil_Wood_Jr.