The NFL rolls out another loaded slate of games this weekend, which in turn provides us with a plethora of different betting options. I'm heading to PrizePicks to get some skin in the game. Below, I've listed my three favorite NFL Week 2 PrizePicks player predictions. If you opt for the PrizePicks power play and all three cash, they'll net us a 6x multiplier.
Get instant alerts when a line reaches your target via the BettingPros App >>
The NFL rolls out another loaded slate of games this weekend, which in turn provides us with a plethora of different betting options. I'm heading to PrizePicks to get some skin in the game. Below, I've listed my three favorite NFL Week 2 PrizePicks player predictions. If you opt for the PrizePicks power play and all three cash, they'll net us a 6x multiplier.
Get instant alerts when a line reaches your target via the BettingPros App >>

Best NFL Week 2 PrizePicks Player Predictions
The Bengals (1-0) escaped Week 1 with a narrow 17-16 victory over the Browns. Up next, they'll host the Jaguars (1-0), who are coming off an easy 26-10 win over the Panthers. Kick-off is scheduled for Sunday at 1:00 p.m. ET from Paycor Stadium in Cincinnati, OH.
I'll be fading Cincinnati's defense all season, and I believe the best way to do so this week is by locking in Trevor Lawrence to clear his passing yardage total. It's a lofty number, but it's well warranted considering the Bengals have a secondary that was ranked 25th in the preseason rankings by Pro Football Focus (PFF). They've already gotten off to a horrid start, conceding 278 passing yards to Joe Flacco and the Browns in week 1.
Trevor Lawrence has only gone over this passing total in one out of his last three full games, but considering the matchup, I think he's competent enough to shred this Bengals pass defense. He logged 178 passing yards in Week 1 against the Panthers, but the team mostly opted to run the ball, considering they had a lead throughout the game. That should change on Sunday in this meeting of two high-profile offenses. I'll take Lawrence going blow-for-blow with Joe Burrow in the passing game.
The marquee matchup this week comes in the Sunday afternoon timeslot, and it's a Super Bowl rematch between the Eagles (1-0) and the Chiefs (0-1). Kick-off is set for 4:25 p.m. ET from Arrowhead Stadium in Kansas City, MO.
The Chiefs did not look good in their Week 1 loss to the Chargers (27-21). They conceded 394 total yards, 304 of which came through the air. Their opposing passing completion rate was 73.5% in that game (27th). They are coming off a season where they ranked just 21st in the category (66.21%). This Kansas City secondary can be exposed, and I'm willing to wager that Jalen Hurts and his Philadelphia offense do so on Sunday afternoon.
This is a great buy-low spot on A.J. Brown, who was targeted only once in Week 1 for one reception and eight yards. That was a complete outlier performance. Last season, Brown averaged 7.5 targets per game, hauling in 5.2 receptions per game. The superstar receiver exceeded 4.5 receptions in six out of his final eight games. I'll take a flier on Brown this weekend against a Chiefs secondary that's still licking its wounds after getting gashed by the Bolts in Brazil last weekend.
Sunday's action wraps up in the Twin Cities, and this contest between the Falcons (0-1) and the Vikings (1-0) has plenty of intriguing storylines. Chiefly, it's the quarterbacking matchup between Michael Penix Jr. and J.J. McCarthy, who squared off in the 2023-24 NCAA Championship game. McCarthy's Michigan Wolverines cruised past Penix's Washington Huskies 34-13 in the game. This Sunday Night Football showdown gets underway at 8:20 p.m. ET from U.S. Bank Stadium in Minneapolis, MN.
Brian Flores didn't blitz against Caleb Williams and the Bears very much on Monday night, as he sent an extra defender on only 32.6% of plays. That's low relative to last season, where the defensive guru blitzed at a league-leading clip of 38.9%. I'm interested to see if this is a permanent change in his defensive philosophy, or perhaps it was a one-game adjustment to avoid getting tormented by the Ben Johnson-led offense that has gotten him several times in the past.
I'm willing to bet that this was a one-off outlier game plan from Flores. If the Minnesota defensive coordinator returns to his blitzing ways, we're going to see Bijan Robinson go nuclear in the receiving department again. Essentially, the theory is that if Penix is under pressure from the blitz, he'll likely distribute the ball quickly to one of his checkdown options (i.e., the running back).
Robinson is always a threat in the receiving game, and that was on display in Week 1 when he went for 100 yards and six catches on seven targets. Last year, the budding star eclipsed 27.5 receiving yards in six of his final 11 games. I'll take him to have a major impact out of the backfield for a second consecutive game.
