NFL Week 6 Picks & Predictions: Best Early Parlays (2026)

Week 6 kicks off in a couple of days, and it's hard to believe how quickly the season is transpiring. Getting to the lines early provides an advantage, and we have identified some that stand out among the rest. Let's dive into our top NFL Week 6 picks and our favorite parlays.

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Best Early NFL Week 6 Picks & Parlays

(Odds Courtesy of DraftKings Sportsbook)

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Early NFL Week 6 Parlay #1

Leg 1: Seattle Seahawks Team Total 22+ Points (-110)

Our first two legs of this parlay focus on the Thursday Night Football matchup between the Seattle Seahawks and Denver Broncos.

Seattle took a devastating loss on their home field against San Francisco on Sunday, and the Seahawks will no doubt be looking to get things back on track. Denver ultimately pulled away from the Chargers in their Week 5 matchup, yet looked incredibly underwhelming in their victory.

Seattle is now 3-2 on the season and cannot spare many more losses. Seattle has scored at least 29 points in four consecutive contests. Despite the two losses, the Seahawks are pouring on the points, and we feel that will continue on Thursday.

Denver is allowing 21.4 points per game - including 24+ points in three out of five games. This is a great spot to consider for a 20-30-point band on the Seahawks to increase your profits.

Leg 2: Jaxon Smith-Njigba 70+ Yards (-248)

There are two avenues that we heavily considered for this leg of the parlay. The first was to take Jaxon Smith-Njigba to score a touchdown, which returns +110.

While that is still very much in play for this contest, dropping the yards total to 70+ on the elite receiver seems to be a much more reliable option. Smith-Njigba is flying over this threshold continuously, and after the tough loss on Sunday, we expect Seattle to look to their most lethal offensive weapon often.

Smith-Njigba is averaging over 116 yards per game through five contests, and has accumulated 70+ yards against every opponent. The Seahawks wide receiver is dealing with an ankle injury that is definitely worth monitoring. However, with the Seahawks in need of a win, it stands to reason that Smith-Njigba will be on the field on Thursday.

With the exception of the game against the Chargers, Denver is allowing 82.5 yards per game to No. 1 WRs.

Leg 3: Bhayshul Tuten 50+ Rushing Yards (-296)

We close out our parlay with a recency bias play that we have been tailing for a few weeks now. It's a tough matchup against a Houston team that is only allowing 78.4 rushing yards per game. Bhayshul Tuten rushed for a season-high 22 attempts in Week 5, resulting in 72 yards. The Jaguars running back has increased his workload over the last four games.

Bhayshul Tuten is averaging 69.8 rushing yards per game this season on 4.3 yards per carry. He has rushed for no fewer than 65 yards. Tuten hasn't had the "home run" day that many are anticipating. Having said that, the young running back has been a model of consistency, and we will continue to back his yards prop until he gives us reason not to.

Parlay Odds: +221

Early NFL Week 6 Parlay #2

Leg 1: Indianapolis Colts Moneyline (-340)

Our second parlay features three Moneyline bets that stand out amongst the crowd. This three-leg parlay will not include an underdog. The return may not be as substantial as one would hope. Our plan is to keep things short and succinct, and with this lineup of outright winners, we feel that can be attained.

While we try to give all teams a kind word, there's very little positive to say about the Tennessee Titans’ current state. It appears they will have the first pick in the upcoming draft. That's at least something to look forward to. As for this season, it's an absolute disaster of epic proportions. The Titans have yet to win and are now on the road against a Colts team that has won two of their last three games.

The Titans have allowed at least 23 points in four out of five games, while averaging nine points of their own over the last three games. Cam Ward has now thrown an interception in three consecutive contests, and has only passed for three touchdowns through five games. The Titans are not showing anywhere near the type of offense it will take to keep up with Indianapolis on Sunday.

Leg 2: Carolina Panthers Moneyline (-105)

The -105 return on this selection is extremely surprising, given the troubles the Philadelphia Eagles are currently facing. It's possible that Carolina coming off a bye and the Eagles being at home are driving the odds towards Philadelphia. Respectfully, we will have to disagree. The Eagles are dealing with all kinds of chaos, and that's not going to help them in a matchup against a young and hungry Carolina squad.

The Eagles are down to rookies and backups on their offensive line. The offensive line for Philadelphia is what has truly set the team apart over the last few years and was a major reason they won the Super Bowl in 2025. Gone are the days of the unstoppable tush push. Instead, it's a dilapidated offense that is currently missing its top wide receiver and running back.

DeVonta Smith and Saquon Barkley each have a chance to return this weekend. However, we are not holding out hope that will save the day. The Eagles have lost three consecutive games, and their only wins this season have come against the Commanders (24-22) in their first contest and the winless Titans (24-20). Carolina is the underdog at the moment. That will more than likely change by Sunday.

Leg 3: San Francisco 49ers Moneyline (-410)

San Francisco continues to pile up wins through the first five games. Kyle Shanahan is locked in right now, and Brock Purdy is an early MVP candidate. The Niners are coming off a phenomenal win on Sunday, when they bested their arch-nemesis, the Seattle Seahawks. San Francisco is currently 5-0 on the season, and take on a Washington team, who on Sunday, displayed some of the worst clock management we have seen all season.

Make no mistake: This is exactly what a trap game looks like. One team is undefeated and just took down their rivals in an epic contest, winning by three points. The other team more than likely spent the last few days agonizing over how they could have been so negligent about the time left on the clock.

This contest should be way tighter than the 7.5-point spread suggests. Nevertheless, San Francisco is clearly the best team in the league going into Week 6, and is more than capable of figuring out how to win a close game on their home field.

Parlay Odds: +214