Skip to main content

Seattle Seahawks vs. Indianapolis Colts Odds & Game Pick (2021)

by September 10, 2021
Russell Wilson

This cross-conference showdown between the Seattle Seahawks and Indianapolis Colts is among the intriguing early-kickoff games on the first Sunday of the new NFL season. Both teams and their fanbases are optimistic about their respective title chances entering the season. Thanks to several moving parts and preseason injuries, the betting line for this game has undergone one of the biggest moves of the week.

Bet $5, Win $200 on Any NFL Team to Win Their Week 1 Matchup >>


Opening Lines: Colts -3; O/U 52
Current Lines: Seahawks -3; O/U 50
Location: Lucas Oil Stadium — Indianapolis, IN
Start Time: 1 p.m. EDT
Last Meeting: October 1, 2017 — The Seahawks defeated the Colts 46-18 in Seattle


The Seahawks have garnered a reputation for their ability to continually live on the edge — and get away with it. Last season saw Seattle post an 8-3 SU record in games decided by eight or fewer points. While quarterback Russell Wilson cooled off dramatically as the season wore on following a blistering start, the Seahawks’ defense continuously improved. This Week 1 matchup presents a similar scenario to last year’s season-opener for Seattle, in which they traveled east and took down the Atlanta Falcons on the road.  

Pretty much all of the key players are back offensively for the Seahawks this season, led, of course, by Wilson. Wideouts D.K. Metcalf and Tyler Lockett form one of the best receiver duos in the NFL. They will be joined this year by free-agent tight end Gerald Everett. Chris Carson will again lead Seattle’s rushing attack. While the Seahawks boast a talented secondary that includes star safety Jamal Adams, the team will need to be better at generating a consistent pass rush than they were a year ago.

With Philip Rivers announcing his retirement, the Colts were forced to make a change at the quarterback position this offseason. Insert former No. 2 overall draft pick Carson Wentz, acquired via trade from the Philadelphia Eagles. The move reunites Wentz with coach Frank Reich, his former offensive coordinator in the Eagles’ Super Bowl-winning season. Unfortunately, a training camp foot injury and ensuing operation limited Wentz in terms of preseason reps. After initially being given a wide-ranging timetable to return, Wentz has officially been ruled active for this Week 1 tilt.

The injury to Wentz, coupled with numerous injuries to the Colts’ star-studded offensive line, led to the drastic move on the point spread for this game. After opening as three-point home favorites, the Colts now find themselves catching that same number even after the positive news regarding their quarterback. Wentz will also be without wideout T.Y. Hilton due to injury. A talented defense figures to keep Indianapolis competitive, but overcoming so many injuries will not be easy.

Check out all of our NFL Game Previews and Picks for Week 1 >>


  • Seahawks went 8-9 against the spread (ATS) last season.
  • The Over was 8-9 for the Seahawks last season.
  • Colts went 9-8 ATS last season.
  • The Over was 10-7 for the Colts last season.
  • Home teams are 4-0, both SU and ATS in the last four head-to-head meetings between the teams.

Bottom Line

If one goes based on the numbers, the Seahawks are again a prime regression candidate this season. However, there are far too many injuries and health concerns on the Colts’ side ahead of this Week 1 matchup to throw caution to the wind on the home underdog. While the lean in this spot has to be towards the home team catching points, bettors’ best bet is to go under the total. The best of the number is gone, but the Under is still in play at the current line of 50. The Colts’ offensive line injuries will aid Seattle defensively. At the same time, Indianapolis’ D will have the home field crowd noise to boost them. A sneaky under, but an intriguing one, nonetheless.

Pick: Under 50

Join the BettingPros Discord Chat for Live Betting Advice >>

Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you’re new to sports betting or a betting pro, our How To Bet and Sports Betting Strategy and Advice pages are for you. You can get started with our Sports Betting 101 Section — including 10 Sports Betting Tips for Beginners — or head to more advanced sports betting strategy — like Key Numbers When Betting Against the Spread — to learn more.

Henry John is a featured writer at BettingPros. For more from Henry, check out his archive.

Game Previews, NFL, Picks