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Indianapolis Colts vs. Buffalo Bills Odds & Game Pick (2021)

by November 19, 2021
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This is an AFC rematch from the Wild Card round last season. That win-or-go-home game was exciting till the very end. The Colts have a different quarterback leading the team, but will we see the same result this week?

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  • Opening Lines: Colts +7 o/u 49.5
  • Current Lines: Colts +7  o/u 50
  • Location: High Mark Stadium
  • Start Time: 1:05 p.m. EDT
  • TV: CBS
  • Last Meeting: January 9, 2021 — Colts 24, Bills 27 (2020 NFL Playoffs: Wild Card Round)

The Colts are continuing to trend upward, especially with how well this offense has played. Running back Jonathan Taylor has been on fire with his fourth game of over 100 yards in five games last week in the 23-17 win against Jacksonville. Indianapolis is starting to creep back into the playoff picture, and a win over the Bills, despite some of Buffalo’s recent performances, would be a big statement.

What’s the best medicine to cure a 9-6 loss the previous week? Play the Jets. The Bills got back into form with a 45-17 beatdown of their division rival. Josh Allen looked like the best Josh Allen in the NFL with 336 passing yards and two touchdowns, and 2020 Stefon Diggs popped up with a season-high 162 receiving yards and touchdown. This team still has the highest-scoring offense and toughest defense, and they are still the best team in the league.

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  • The OVER is 11-3 in Indianapolis’ last 14 road games.
  • The OVER is 6-6 in Buffalo’s last 12 games.
  • Indianapolis is 5-3 against the spread as an underdog in 2021.
  • Indianapolis is 8-2 against the spread in their last 10 games on the road.


The Colts have played most of their games tough and close. In the first six of seven games they were the underdog, covering four of them, including one over seven points. The way Jonathan Taylor has been playing recently, he can attack this tough Buffalo defense, giving just enough breathing room for Carson Wentz to make some plays to keep it close. They don’t have a great chance to beat Buffalo on the road, but they’ll keep it competitive.

Pick: Colts +7

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