NFL Parlays & Picks: Best Bets for Week 13 (2025)

NFL Week 13 gets underway early during the holidays. Three Thanksgiving matchups will be played on Thursday, followed by a Black Friday matchup between the Chicago Bears vs. Philadelphia Eagles on Prime Video.

My NFL Parlays & Picks: Best Bets for Week 12 (2025) settled 0-2. Despite neither parlay winning, two winners came home if you bet them straight, including the Vikings vs. Packers under 41.5 points and Texans +4.5 in an upset win over Buffalo on Thursday Night Football. Losers were the Saints’ moneyline and Jaguars vs. Cardinals under 47.5.

Let’s bet current value in the NFL Week 13 markets and build a pair of early winning parlays to enjoy the long holiday weekend. Follow me on X at Matt_MacKay_ for more NFL betting analysis and free picks.

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NFL Early Week Parlays: Week 13

(Odds courtesy of FanDuel Sportsbook)

Parlay 1 (+111)

Leg 1: Detroit Lions Moneyline (-152)

Thanksgiving starts with an NFC North matchup at Ford Field. The Detroit Lions survived a scare with an overtime win over the New York Giants in Week 12. Now, the Lions host the Green Bay Packers as a -152 betting favorite.

Detroit’s defense had an uncharacteristic outing against Jameis Winston’s Giants, allowing 395 passing yards. Jordan Love has struggled to get a lot of production within Green Bay’s offense, logging under 300 total yards of offense in three straight games.

Jahmyr Gibbs has been on full display since Lions head coach Dan Campbell took over play-calling. Micah Parsons and the Packers’ defense are a stout unit, but Gibbs is an elite, explosive athlete in the run and passing game.

After beating Detroit 27-13 in Week 1, expect the Lions to have revenge on their mind. Detroit plays its best brand of football at home, so let’s jump on this line and bet on the Lions as a marginal home favorite against an underwhelming Green Bay offense.

Leg 2: Philadelphia Eagles Moneyline (-360)

The Eagles were shut out by the Cowboys in the second half of their 24-21 road loss in Dallas during Week 12. Philadelphia blew a 21-0 lead, only generating 63 rushing yards. Now, they return home to host a surging Chicago Bears team.

Ben Johnson’s first year in Chicago has transformed the Bears’ franchise. Chicago is now 8-3, winning four consecutive games, including six of their last seven. The defense has returned to form, forcing multiple turnovers in back-to-back games against the Vikings and Steelers.

The Eagles are still trying to find their identity. Defense is the most reliable unit right now, although they were just exploited by Dallas’ passing attack, giving up 348 yards through the air in Week 12.

We’ve seen Philadelphia lose back-to-back games against the Giants and Broncos back in early October. They’ve won convincingly at home in their last two appearances, routing the Giants 38-20, before shutting down the Lions in a 16-9 victory on Sunday Night Football in Week 11.

The Bears have had a lot of close finishes and luck on their side. Now, they go on the road during a short week to play an Eagles team eager to get back on the field after an embarrassing collapse.

We’re backing Philadelphia on the moneyline at a heavy -360 price to bump this first NFL early Week 13 moneyline parlay to plus odds.

Parlay 2 (+249)

As long as Houston keeps being valued as an underdog, we’re going to bet taking their point spread. C.J. Stroud is expected to return to the Texans’ lineup in Week 13, sending him on the road to face the 8-3 Indianapolis Colts.

This AFC South divisional matchup has big implications for playoff seeding. It’s the first time these teams will play each other in 2025. Houston is only two games behind the Colts, who just lost 23-20 in overtime to the Chiefs. Colts RB Jonathan Taylor is having an MVP-caliber season, but he was held out of the end zone in Week 12, recording only 58 total rushing yards.

The Texans, under head coach DeMeco Ryans, roster the NFL’s second-ranked scoring defense. Houston has allowed 16.5 points per game on average, completely overwhelming Josh Allen in the pocket to pull off an upset as a home underdog over the Bills in Week 12.

Daniel Jones has been prone to turnovers throughout his career. Indianapolis may struggle to get the run game going in this matchup, meaning Jones will have to shoulder the load against Houston’s elite defensive unit.

Even without Stroud, QB Davis Mills has led the Texans to a 3-0 record. Let’s jump on Houston +4.5 right now before it moves down to +3.5 or +2.5 later in the week. After all, the Texans have covered this number in five straight games.

Leg 2: Minnesota Vikings vs. Seattle Seahawks – Under 42.5 (-115)

Sam Darnold gets a revenge game against Minnesota as a -9.5 point home favorite in Week 13. The Seattle Seahawks have shown they have Super Bowl aspirations with their 8-3 record under head coach Mike Macdonald.

The Seahawks are the league’s third-best scoring offense and also deploy a top-10 scoring defense, making them a tough out for any opponent. Minnesota has struggled mightily with second-year quarterback J.J. McCarthy. After moving on from Darnold following a 14-win season, McCarthy is 2-4 as a starter.

Seattle’s pass defense is going to have a field day against McCarthy. He has a 54 percent completion rate, six touchdown passes, and 10 interceptions in 2025. This includes two interceptions thrown in three consecutive starts.

McCarthy has only thrown for more than 160 yards once during his six starts. It won’t happen against the Seahawks’ lockdown secondary.

Minnesota’s best unit is on defense. Under DC Brian Flores, the Vikings have held four straight opponents under 321 total yards of offense. Familiarity with Darnold could make this game a defensive slugfest, although there’s a reason Seattle is a 10-point favorite.

Let’s bet under 42.5 total points in this matchup that features a bottom-10 offense and a top-10 defense.