It’s Week 16 of the NFL season, and following Thursday's game between the Rams and the Seahawks, the league has games scheduled on Saturday, Sunday and Monday. Let's pick it up with Sunday's 12-game slate, where I've narrowed in on a trio of NFL Week 16 PrizePicks player predictions. If you opt for the PrizePicks Power Play and all three hit, it'll net us a 6X multiplier.
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It’s Week 16 of the NFL season, and following Thursday's game between the Rams and the Seahawks, the league has games scheduled on Saturday, Sunday and Monday. Let's pick it up with Sunday's 12-game slate, where I've narrowed in on a trio of NFL Week 16 PrizePicks player predictions. If you opt for the PrizePicks Power Play and all three hit, it'll net us a 6X multiplier.
Get instant alerts when a line reaches your target via the BettingPros App >>

Best NFL Week 16 PrizePicks Player Predictions
Following a 2-0 start to the season, the Cardinals (3-11) have gone on to win just one of their subsequent 12 games. This includes their current six-game slide, which they'll try to snap on Sunday when they host the Falcons (5-9). This NFC battle gets underway at 4:05 p.m. ET from State Farm Stadium in Glendale, AZ.
Jacoby Brissett has been a garbage-time hero this season. The journeyman backup has slung 18 touchdowns (19th) in nine starts, which equates to exactly two touchdown passes per start. He's on an 8-1 run with multi-touchdown outings. Marvin Harrison Jr. (heel) is listed as questionable, but considering he can hardly catch anyway, I don't think it'll be a dealbreaker if he's unable to play. What's most important is that star tight end Trey McBride (10 touchdowns) and the emerging Michael Wilson (four touchdowns) will both be in the lineup.
This is a decent matchup for Brissett and the pass-heavy Cardinals, who throw the ball on 65.4% of plays (second). The Falcons allow opposing quarterbacks to complete 63.5% of their passes (15th). They're also 15th in red-zone defense (58.1%) and 19th in third-down rate (39.8%). Let's ride the red-hot Brissett against this Atlanta secondary that has conceded six touchdown passes in its last three games.
Like the Cardinals, it has been an abysmal season for the Raiders (2-12). They find themselves as 14.5-point road underdogs when they take on the upward-trending Texans (9-5), who have won their last six games. Kick-off is scheduled for 4:25 p.m. ET from NRG Stadium in Houston, TX.
Former Las Vegas offensive coordinator Chip Kelly enjoyed giving Ashton Jeanty a heavy workload early in the season, but since his departure in Week 12, Jeanty's production has dropped off significantly. In the three games without Kelly, Jeanty is averaging only 15.3 touches per game. This has dragged his season-long average down to 17.8 touches per game (12th).
Jeanty has been stonewalled in terms of production during those three games, averaging only 47 combined rushing + receiving yards per game. He has failed to eclipse this lofty 73.5-yard line in five of his last six games. I don't see Jeanty and this ugly Raiders offense turning things around against the Texans' elite defense. Pro Football Focus (PFF) grades Houston third in the NFL against the run (77.6), and they're allowing only four yards per carry (10th) and 92.7 rushing yards per game (fourth). Give me the less than 73.5 scrimmage yards for Ashton Jeanty this weekend.
The Ravens (7-7) bounced back with a 24-0 victory over the Bengals last weekend, and they'll attempt to stay in the playoff hunt on Sunday Night Football when they take on the Patriots (11-3). This contest is set for 8:20 p.m. ET from M&T Bank Stadium in Baltimore, MD.
There are a lot of mouths to feed in Baltimore, so when combining the lack of target share with the theory that Mark Andrews may be past his prime, it starts to make sense why he's a bottom-tier tight end this season. The 30-year-old is 73rd in receptions (40) and 92nd in receiving yards (359). He hasn’t cleared 33.5 receiving yards in 11 of his 14 games this season, with one of the outliers being a 34-yard outing against the Bears. Considering the Ravens aren't looking nearly as dynamic as we've seen in years past, I'm honestly surprised to see this line in the 30s.
New England has also graded out as one of the better pass defenses in the NFL. They are ranked fifth in coverage (79.1) by PFF, as well as fourth in tackling (71.7). The Patriots are allowing only 6.4 yards per pass attempt (11th) and 205.1 passing yards per game (15th). Considering all angles, I just don't see Andrews having a huge impact in this one. I'm backing the less than on his receiving yards.
