The non-stop Premier League action resumes on Tuesday with an under-the-radar matchup between West Ham and Nottingham Forest. The squads are jockeying for the final relegation spot heading into Matchday 21. Atop the table, Arsenal continues its dominant campaign, now sitting six points clear of second-place clubs Manchester City and Aston Villa. The Gunners are currently priced at -350 to win their first Premier League title since 2003-04.
I've got you covered from a betting angle for this midweek slate of Premier League soccer. Below, you'll find my top three Premier League Matchday 21 bets.
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Premier League Matchday 21 Preview & Best Bets (2025)
(Odds courtesy of DraftKings Sportsbook)
Crystal Palace (+205) vs. Aston Villa (+135), DRAW (+235) | O/U 2.5 (-110/-115)
Aston Villa (13-3-4) had its 11-match winning streak snapped last week, but they bounced back with a comfortable 3-1 home victory over Nottingham Forest this past weekend. Up next, they'll take on sliding Crystal Palace (7-6-7), who have dropped to 14th place courtesy of a 0-1-4 Premier League run. Kick-off is scheduled for Wednesday at 2:30 p.m. ET from Selhurst Park in London.
We've cashed in a few times on Aston Villa's insane 12-0-1 run across all matches. I'm going right back to Unai Emery's club on Wednesday. How can we pass up on this sweet plus-money payout that comes with the Villans on the moneyline? During the 13-game stretch, Aston Villa has out-scored its opposition 30-16, posting three clean sheets along the way.
Meanwhile, Crystal Palace's hot start to the season has come to a screeching halt. They've collected just one point across their last five Premier League matches, spiraling down to 14th place in the process. During the five-match sample size, they've been out-scored 11-2 and have been blanked three times. Palace is an underwhelming 2-5-3 at home this season, so red-hot Aston Villa shouldn't have to worry about running into any fierce home-field advantage in this match.
Bet: Aston Villa Moneyline (+135)
Burnley (+360) vs. Manchester United (-140), DRAW (+300) | O/U 2.5 (-140/+110)
Manchester United (8-7-5) has secured a result in seven of its last eight matches (3-4-1), but the front office still decided to sack manager Ruben Amorim over the weekend. This comes after a 1-1 road draw against Leeds United. Manchester United should keep their point-filled run alive on Wednesday when they square off against lowly Burnley (3-3-14), who enter Matchday 21 ranked 19th. This match gets underway at 3:15 p.m. ET from Turf Moor in Burnley.
With Amorim ousted, it has paved the way for Darren Fletcher to take the reins of Manchester United. He was previously serving as the U18 manager for the organization. Fletcher draws a very favorable matchup in his top-flight debut, as he'll be coaching against a Burnley side that is just 3-3-14 with a -19 goal differential (20:39). In terms of expected goals allowed, the Clarets are ranked dead last with a mark of 38.5. Let's back Manchester United to secure the win in their coach's debut. They have plenty of offensive firepower (third in scoring with 34 goals) to take care of 19th-ranked Burnley.
Bet: Manchester United Moneyline (-140)
Arsenal (-165) vs. Liverpool (+425), DRAW (+320) | O/U 2.5 (-140/+110)
The matchday wraps up with a marquee, top-five battle between top-ranked Arsenal (15-3-2) and fourth-place Liverpool (10-4-6). This is a standalone game on Thursday, which is set for 3:00 p.m. ET from Emirates Stadium in London.
I'm taking a plus-money shot on the under 2.5 goals in Thursday's match. Arsenal continues to stifle opposing offenses, as they enter the matchday ranked first in both goals allowed (14) and expected goals allowed (xGA) with a mark of 14.5. Remember, they've played 20 matches, so that equates to allowing only 0.7 goals per match. The Gunners also lead the Premier League with nine clean sheets, and their 45% clean sheet rate also tops the Premier League ranks.
Meanwhile, Liverpool has looked sharp defensively as of late. Across their last six matches in all competitions, the Reds have logged three clean sheets and are allowing 0.7 goals per game. Overall in the Premier League this season, Arne Slot's squad is a pedestrian 11th in goals allowed (28), but ranks fourth in xGA (23.3). Liverpool notched a 1-0 home win over Arsenal on August 31st, and I anticipate another low-scoring affair in this high-stakes match. Give me the under.
Bet: Under 2.5 Goals (+110)
