The Premier League has been idle for just over a week, with the Emirates FA Cup taking center stage last weekend. Reigning Emirates FA Cup champions Crystal Palace were stunned in a 2-1 defeat by sixth-tier Macclesfield FC. This speaks to the poor form of the Eagles, who have posted an ugly 0-2-3 record across their last five English Premier League (EPL) matches. Crystal Palace now resides in 13th place in the EPL, trailing first-place Arensel by 21 points.
All 20 teams are set to take the pitch this weekend, and I've got you covered from a sports betting perspective. Let's dive into my top three Premier League Matchday 22 bets.
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Premier League Matchday 22 Preview & Best Bets (2025)
(Odds courtesy of DraftKings Sportsbook)
Liverpool (-425) vs. Burnley (+1000), DRAW (+550) | O/U 2.5 (-180/+140)
Let's pick it up on Saturday morning, where we have an intriguing tilt between Liverpool and Burnley. The Reds currently sit in fourth place at 10-5-6 (35 points), while the Clarets are below the relegation line in 19th (3-4-14, 13 points). Kick-off is scheduled for 10:00 a.m. ET from Anfield in Liverpool.
Initially, I was leaning towards laying two goals (+110) with Liverpool, but upon diving deeper into their schedule, I noticed that Arne Slot's crew have struggled to secure multi-goal wins this season. Instead, I'll lean on the Reds' defense and back them to keep a clean sheet. Liverpool has a pair of clean sheets in its last three Premier League outings. Overall this season, they've kept the opposition scoreless in seven of their 21 matches (33.3%).
With the Anfield crowd behind them, I expect Liverpool's defense to hold up well. Burnley's not much of an offensive powerhouse, entering the matchday ranked 17th in goals scored (22) and dead last in expected goals (xG) with a mark of 17.9. The Clarets have been blanked in two of their last four Premier League games, and they've failed to score in seven of their 21 matches this term. I'll fade their offense to get the day started on Saturday.
Bet: Liverpool Team Clean Sheet: Yes (-135)
Wolverhampton (+350) vs. Newcastle United (-135), DRAW (+310) | O/U 2.5 (-135/+120)
Sunday's two-match slate opens up with Wolverhampton hosting Newcastle United. The Wanderers have picked up points in three straight games, but they're still in the cellar of the Premier League table at 1-4-16 (seven points). The Visitors are vying for a coveted top-four spot, currently sitting in sixth place at 9-5-7 (32 points). This contest gets underway at 9:00 a.m. ET from Molineux Stadium in Wolverhampton.
Wolverhampton has been on an upward trend, going 2-2-0 across its last four matches in all competitions. This feels like a great sell-high point, as Wolverhampton welcomes in a Newcastle side that's firing on all cylinders. The Magpies have won their last three Premier League games, racking up nine goals in the process. Newcastle is now a respectable 12th in scoring (32 goals), while ranking 10th in xG (31). Eddie Howe's squad has plenty of firepower to outpace the hosts, and this is a game that they must win if they're serious about making a push for the top four.
Offense has been tough to come by for Wolverhampton this season, as they're 20th in scoring (15 goals) and 18th in xG (19.8). I'd like to remind everyone that teams have played 21 matches, so this squad is averaging fewer than a goal per game. Wolverhampton's -26 goal differential (15:41) is also the worst in the league. It may have been a fun run picking up some points recently, but I expect reality to kick back in on Sunday for a lowly Wolverhampton club. I'll take Newcastle United to secure the three points.
Bet: Newcastle United Moneyline (-135)
Brighton (-115) vs. Bournemouth (+270), DRAW (+290) | O/U 3.5 (+120/-160)
The matchday concludes on Monday with a bottom-half showdown between 11th-place Brighton (7-8-6, 29 points) and 15th-place Bournemouth (6-8-7, 26 points). Kick-off is slated for 3:00 p.m. ET from American Express Stadium in Falmer.
Bournemouth has been an over machine as of late, seeing four or more goals in five straight matches, as well as in six of its last seven in all leagues. With the way the Cherries are playing currently, I'll take a +120 flier on the over of 3.5 goals. Bournemouth have struggled to keep the ball out of its net, as the Falmer club comes into the contest ranked 17th in goals allowed (40) and 18th in xGA (31.2). They've allowed two or more goals in 12 of their 21 matches this season.
Meanwhile, Brighton hasn't been the poster child for great defense either. They're 12th in goals allowed (28) and 13th in xGA (30). The Seagulls' 23.8% clean sheet rate is just 14th in the league. With Bournemouth scoring multiple goals in four straight games across all competitions, it leads me to believe we'll have enough offense to sneak over this number. I'll predict a 2-2 draw or a 3-1 Brighton victory. Give me the over.
Bet: Over 3.5 Goals (+120)
