Arsenal picked up a huge 2-1 home win over Chelsea on Sunday, helping the Gunners maintain a five-point cushion atop the English Premier League table. The London-based squad is priced at -230 to win the league, while second-place Manchester City - the only other team in contention - sits at +175 to secure the title. It's worth noting that Manchester City has a game-in-pocket to try and narrow the gap.
We have a few exciting matchups on the docket this week, including Aston Villa taking on Chelsea in a top-six clash. Below, I'll dive into that match, as well as two others, from a sports betting angle. Here are my top English Premier League Matchday 29 picks & predictions.
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Premier League Matchday 29 Preview & Best Bets (2026)
(Odds courtesy of DraftKings Sportsbook)
Aston Villa (+170) vs. Chelsea (+150), DRAW (+260) | O/U 2.5 (-145/+115)
Let's pick it up on Wednesday afternoon, where Aston Villa (15-6-7, 51 points) gears up to host Chelsea (13-9-7, 25 points). Kick-off is scheduled for 2:30 p.m. ET from Villa Park in Birmingham.
Aston Villa is on the heels of an ugly 2-0 road loss to the lowly Wolverhampton Wanderers over the weekend. This affair gave Wolverhampton its second win of the season in 29 tries. With neither team really being in great form at the moment, I think we could see this match end in a draw (+260).
Chelsea has probably been the better team as of late, but there's simply no ignoring Aston Villa's strong home-field advantage. The Villans are the fourth-best team at home this season, going 9-2-3 with a +9 goal differential (20:11). Meanwhile, the Blues are a modest 6-4-4 on the road this year.
Both defenses have been sound this term, which leads me to believe we could be in for a low-scoring draw. Chelsea is third in clean sheet rate (32.1%) and seventh in save percentage (68.5%), while Aston Villa is seventh (28.6%) and second (73.4%), respectively. I'll predict a 1-1 final score.
Bet: Draw (+260)
Newcastle United (+155) vs. Manchester United (+160), DRAW (+275)
Wednesday's five-match slate concludes with an intriguing contest between Newcastle United (10-6-12, 36 points) and Manchester United (14-9-5, 51 points). Newcastle has slid to 13th place, while Manchester United has ridden a 6-1-0 run up the standings into third place. This game gets underway at 3:15 p.m. ET from St. James' Park in Newcastle upon Tyne.
I'm taking it to the prop sheet in this one, playing Benjamin Sesko to score for Manchester United. For starters, the 22-year-old forward has been lighting it up recently, scoring in three straight games, as well as in four of his last five outings. Sesko is averaging 2.2 shots and 1.6 shots on target per game during the five-match sample size. He's second on Manchester United's roster in goals (eight) this year, behind only Bryan Mbeumo (nine).
This is a decent matchup for Sesko and the red-hot Manchester United offense. They'll be looking to score on a Newcastle defense ranked 14th in both goals allowed (42) and shots on target allowed (114). The Magpies are giving up an uninspiring 1.50 goals per 90, which is also 14th in the Premier League. They've conceded two or more goals in three consecutive matches across all competitions. Give me Sesko to bury one at +245 odds.
Bet: Benjamin Sesko Anytime Goal Scorer (+245)
Tottenham Hotspur (+140) vs. Crystal Palace (+200), DRAW (+235)
The matchday concludes with a standalone clash on Thursday between Tottenham (7-8-13, 29 points) and Crystal Palace (9-8-11, 35 points). The Lilywhites are hoping to snap a four-game Premier League slide, while the visitors are looking to bounce back from a 2-1 road loss to Manchester United over the weekend. The Matchday 29 finale is slated for 3:00 p.m. ET from Tottenham Hotspur Stadium in London.
This has been a horrendous stretch of soccer for Tottenham Hotspur. They've lost four straight matches in the Premier League and now sit only four points above the relegation line. This four-game slide is a part of a larger 10-game winless sample, where the Lilywhites are 0-4-6. You have to go back to December 28th to find their last win, which came in a 1-0 affair against Crystal Palace.
That victory over Crystal Palace is the only one for Tottenham Hotspur in the last three head-to-head meetings. The Eagles had previously won the last two, including notching a 2-0 shutout win in London last May. I'll back Crystal Palace on the Moneyline at +200 in this match. They've managed to win six of their 14 road games (6-2-6) this year, and will take on a Tottenham Hotspur side that's only 2-4-8 at home in 2025-26.
Crystal Palace brings in the sixth-best defense in terms of goals allowed (34), while ranking third in save percentage (73%). With their defense in solid form, I'm willing to wager that Oliver Glasner's men can grind out a low-scoring road win.
Bet: Crystal Palace Moneyline (+200)
