Top 3 MLB Picks & Predictions: Saturday (6/6)

Our MLB picks columns are still in the black for the season after turning in profits in three of the previous four weeks. Today’s best bets are centered around favorites, with one Moneyline play and two run line plays for better value.

Here are the best MLB picks & predictions for Saturday, June 6th.

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Saturday’s Best MLB Picks & Predictions

Odds courtesy of DraftKings Sportsbook | This Season: 15-15 (+0.62 units)

Kansas City Royals at Minnesota Twins

Entering this series, the Royals were 5-22 in their last 27 games at Target Field, while averaging just 2.8 runs per game over that span. Therefore, I am not going to overreact to Kansas City’s rare offensive breakout in an 8-6 win on Thursday, as it went 4-16 over a 20-game stretch last month.

Joe Ryan has won two of his last three starts, and Minnesota is 5-1 overall in his last six outings. Three of those wins came against teams currently in the playoff picture, and the one loss was a one-run loss to a Brewers team who has MLB’s best record over the last month.

Ryan has made quality starts in three of his last four outings, with a 34:1 K:BB ratio over 25.2 innings. He is fifth in MLB in fWAR coming off an All-Star season, and Kansas City is 3-8 in Luinder Avila’s 11 appearances, with a -32 run differential.

Pick: Twins Moneyline (-149)

Milwaukee Brewers at Colorado Rockies

Entering this series, Milwaukee was an MLB-best 19-7 since May 6th with a +47 run differential over that span. And going back further to May 1st, the Brewers’ pitching staff owned the best ERA (2.47), xERA (2.96) and FIP (2.77) of any team in the Majors up to yesterday.

A big reason for Milwaukee’s pitching success was Jacob Misiorowski, who turned in a historic month of May. He is 5-0 over his last six starts spanning 38.1 innings, with a 0.23 ERA, 57:6 K:BB ratio and a .109 opponents’ average.

In 2025, Misiorowski had a 57.9% first-pitch strike rate. This year, that first pitch strike rate is 65.2%, which is the fifth-highest increase by any pitcher over the last two seasons (minimum 35 innings).

Seemingly, no opposing lineup can touch Misiorowski’s fastball, as his 43.9% whiff rate on the pitch leads the Majors. The next-highest is Cam Schlittler’s 33.6% whiff rate (minimum of 250 fastballs thrown).

Jacob Misiorowski & Kyle Harrison last 13 starts (combined):

0.58 ERA | 112-15 K-BB (78.0 IP)⁰.151/.198/.199 (.396 Opp OPS)⁰4.2 fWAR | 12-1 Brewers W-L pic.twitter.com/pT1iNuIQYq

- Paul Hembekides (Hembo) (@PaulHembo) June 3, 2026

I don’t see Colorado keeping Milwaukee’s offense in check enough to compete with Misiorowski, especially since Tanner Gordon ranks in the 27th percentile or worse in xBA, xERA, hard-hit rate and barrels.

Pick: Brewers -2.5 (-121)

Los Angeles Angels at Los Angeles Dodgers

The Angels ended their last series scoring 10+ runs for the third time in the last nine games, which matched their total of 10-run games from the previous 54 games. But the Rockies’ pitching staff is much different than the Dodgers’ staff, and the Angels scored just three total runs while being out-scored 31-3 in an embarrassing three-game sweep against their in-state rivals last month.

The Dodgers’ offense has taken off lately with the re-emergence of Shohei Ohtani. Over 180 plate appearances through May 11th, Ohtani was slashing .233/.363/.404 with six home runs. Since May 11th, entering yesterday, he has made 90 plate appearances and is slashing .438/.533/.753 with four home runs, leading the Majors in all categories over that span (minimum 60 plate appearances).

Jack Kochanowicz allowed three home runs in his last start against the Dodgers, and I'm banking on several Dodgers, not just Ohtani, joining the hit parade tonight.

Pick: Dodgers -1.5 (-162)

Mike Spector is a featured writer at BettingPros. For more from Mike, check out his archive and follow him @MikeSpector01.