The Chicago White Sox look to build on their 1-0 series lead when they visit the Cleveland Guardians for Game 2 of the ALDS on Monday, October 5. Anthony Kay is scheduled to face Gavin Williams, with Cleveland seeking a home win before the series shifts to Chicago. The pitching matchup provides a starting point for evaluating strikeout props, while lineup placement and potential bullpen matchups help shape the outlook for hits and total bases. Below, we highlight our best White Sox vs. Guardians MLB player props and picks for Monday's playoff matchup.
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Today’s Best MLB Player Props & Bets: White Sox vs. Guardians
Here are the best MLB player prop bets for today’s game White Sox vs. Guardians.
Chicago White Sox vs. Cleveland Guardians
Miguel Vargas had great numbers against Cleveland in the regular season, posting a .424 on-base percentage (OBP) with six extra-base hits and 10 RBI. He is the only White Sox hitter to have homered off Daniel Espino (in a small two-at-bat sample), and both of his hits against Joey Cantillo in six at-bats were extra-base hits.
Vargas turned in his first career 30-homer season. He and Colson Montgomery were the first White Sox teammates to hit 30+ home runs in the same year since Jose Abreu and Eloy Jimenez in 2019.
They were also the first set of teammates to reach that milestone this season, marking just the second time in franchise history that White Sox teammates were the first to reach 30 home runs in the Majors (joining Jermaine Dye and Jim Thome in 2006).
Miguel Vargas To Hit A Home Run (+425)
More MLB Player Props & Bets for White Sox vs. Guardians
We compiled several projection sources to come up with consensus projections. We then compared these projections to the prop bet odds from the sportsbooks to give you the best MLB player props, bets and picks. Let’s take a look at the top player props, bets, odds, rankings, and picks for White Sox vs. Guardians.

Phil Wood is a featured writer at BettingPros. For more from Phil, check out his archive and follow him @Phil_Wood_Jr.
