The 2026 Major League Baseball (MLB) regular season continues today, with eight matinee games, and seven first pitches at 6:45 p.m. ET or later. The Chicago White Sox and New York Yankees meet at 7:05 p.m. ET on Prime Video. We’ll focus on the evening games, giving you more time to place your bets. Let’s build our bankroll with our best MLB picks & predictions for Wednesday, June 17th.
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Wednesday’s Best MLB Picks & Predictions
Odds courtesy of FanDuel Sportsbook | All bets are for 1 unit
Toronto Blue Jays (+108) at Boston Red Sox (-126) | O/U 9.5 (-102/-118)
The Blue Jays (35-38) and Red Sox (29-41) meet at Fenway Park at 6:45 p.m. ET. Toronto picked up a 6-1 victory as light favorites (-120) in Tuesday’s series opener behind righty Dylan Cease, who struck out seven batters across five innings while only allowing four hits, four walks and zero earned runs.
The win for Toronto snapped a mini two-game losing streak. The Blue Jays are still just 3-4 over the past seven outings, while the under has gone 2-1 in the past three games and 4-3 in that same seven-game span. Boston has dropped two in a row and is just 2-6 in the past eight games. The under on Tuesday halted a four-game run to the over.
Toronto turns to veteran righty Max Scherzer (1-4, 10.23 ERA, 1.73 WHIP), who has struggled in 22 innings across six starts this season. He has allowed at least five runs in three of his past four outings, while serving up multiple homers in three of the past four starts.
Boston counters with lefty Jake Bennett (1-2, 5.28 ERA, 1.50 WHIP). Across his first three MLB starts, he has walked five batters while striking out just eight. These two pitchers could be rather giving, and that’s why the over is the best play, perhaps on the entire board today. We’ll also back the Red Sox, as Scherzer has been an absolute disaster this season, and you can’t bet good money on him.
Picks: Red Sox Moneyline (-126) & Over 9.5 Runs (-102)
Cleveland Guardians (+102) at Milwaukee Brewers (-120) | O/U 7.5 (-115/-105)
The Guardians (39-34) and Brewers (44-26) meet at American Family Field for the second installment of their three-game Interleague series.
In Tuesday’s series opener, the Brewers edged the Guardians 2-1 in an unexpected pitcher’s duel between Cleveland’s Slade Cecconi and Milwaukee’s Robert Gasser. What can these teams do for an encore?
Guardians righty Gavin Williams (9-3, 3.32 ERA, 1.10 WHIP) gets the starting nod, and he looks to improve on his 99 strikeouts, which is tied for fifth in the Majors. The Brewers turn to righty Brandon Sproat (1-4, 5.70 ERA, 1.48 WHIP) for his 12th start and 14th appearance of the season.
Williams is looking like an All-Star this season. He is aiming for his 10th victory of the season, but his offensive support took a big hit when Jose Ramirez broke a bone in his hand on Saturday. He’ll be out indefinitely, so that’s a tough one for the Cleveland offense. It managed just a single run in the first full game without Ramirez.
Despite the fact that Ramirez is sidelined and Cleveland managed just a single run against Gasser, let’s take the Guardians to get the job done behind Williams. And, we’ll go low on the total yet again.
Picks: Guardians Moneyline (+102) & Under 7.5 Runs (-105)
Baltimore Orioles (+120) at Seattle Mariners (-142) | O/U 7.5 (-110/-110)
The Orioles (34-40) and Mariners (38-36) tangle again at T-Mobile Park in Seattle on Wednesday. In the series opener, the Mariners scratched out a 3-1 win, as the under cashed for the first time in five meetings between these teams this season. The over is still 2-1-2 in five matchups in 2026, while the M’s hold a slight 3-2 series edge this season.
Baltimore is just 12-21 on the road, while Seattle is 20-16 at home. The O’s are sending righty Kyle Bradish to the bump (3-7, 4.30 ERA, 1.57 WHIP), while the M’s roll with righty George Kirby (5-6, 4.07 ERA, 1.31 WHIP).
Kirby has actually struggled more at home, posting a 4.56 ERA in 47.1 innings across eight starts, while serving up six of his eight home runs. However, Bradish has been horrendous on the road, going 1-4 with a 6.18 ERA, more than three runs above his home ERA (3.15). He has allowed 39 walks and 11 homers this season in 14 starts.
We’re going to go with the Mariners at home, and hope that Kirby can solve his woes at T-Mobile Park. Let’s go high on the total, too, based on the series trends.
Picks: Mariners Moneyline (-142) & Over 7.5 Runs (-110)
Joe Williams is a featured writer at BettingPros. For more from Joe, check out his archive and follow him @winwithjoe